Pharmacokinetics and Ex Vivo Pharmacodynamic Antimalarial Activity of Dihydroartemisinin-Piperaquine in Patients with Uncomplicated Falciparum Malaria in Vietnam
Pharmacokinetics and Ex Vivo Pharmacodynamic Antimalarial Activity of Dihydroartemisinin-Piperaquine in Patients with Uncomplicated Falciparum Malaria in Vietnam
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DOI：
10.1128/aac.01717-08
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发表时间：
2009-08-01
影响因子：
4.9
通讯作者：
Edstein, Michael D.
中科院分区：
文献类型：
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作者：
Dao Van Hoang Nguyen;Quoc Phuc Nguyen;Edstein, Michael D.
与健康受试者相比，疟疾患者在用双氢青蒿素-哌喹（Artekin）治疗无并发症的恶性疟原虫后，越南患者的双氢青蒿素平均口服清除率（1.19 vs 5.87升/小时/千克体重）和表观分布容积（1.47 vs 8.02升/千克）降低。双氢青蒿素负责双氢青蒿素-哌喹的大部分离体抗疟活性。
Compared to healthy subjects, malaria patients show a reduction in the mean oral clearance (1.19 versus 5.87 liters/h/kg of body weight) and apparent volume of distribution (1.47 versus 8.02 liters/kg) of dihydroartemisinin in Vietnamese patients following treatment with dihydroartemisinin-piperaquine (Artekin) for uncomplicated Plasmodium falciparum. Dihydroartemisinin is responsible for most of the ex vivo antimalarial activity of dihydroartemisinin-piperaquine.