Explicit equilibrium modeling of transcription-factor binding and gene regulation
Explicit equilibrium modeling of transcription-factor binding and gene regulation
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DOI：
10.1186/gb-2005-6-10-r87
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发表时间：
2005-01-01
期刊：
影响因子：
12.3
通讯作者：
Clarke, ND
中科院分区：
文献类型：
--
作者：
Granek, JA;Clarke, ND
我们已经开发了一个计算模型，可以预测转录因子与基因组中任何位置结合的可能性。GOMER(广义占有率表达调控模型)以位置权重矩阵为基础计算结合概率，并通过显式计算耦合结合平衡来考虑协作性和竞争的影响。戈默可以用来检验关于基因调控的假说，这些假说建立在蛋白质-DNA结合的物理原理预测的基础上。
We have developed a computational model that predicts the probability of transcription factor binding to any site in the genome. GOMER (generalizable occupancy model of expression regulation) calculates binding probabilities on the basis of position weight matrices, and incorporates the effects of cooperativity and competition by explicit calculation of coupled binding equilibria. GOMER can be used to test hypotheses regarding gene regulation that build upon this physically principled prediction of protein-DNA binding.