Magnetic resonance T2-relaxometry and 2D L-correlated spectroscopy in patients with minimal hepatic encephalopathy.
Magnetic resonance T2-relaxometry and 2D L-correlated spectroscopy in patients with minimal hepatic encephalopathy.
复制标题
轻微肝性脑病患者的磁共振 T2 弛豫测量和 2D L 相关光谱。
DOI：
10.1002/jmri.21943
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Thomas,MAlbert
中科院分区：
文献类型：
--
作者：
Singhal,Aparna;Nagarajan,Rajakumar;Kumar,Rajesh;Huda,Amir;Gupta,RakeshK;Thomas,MAlbert
PurposeTo evaluate T2‐relaxation changes in patients with minimal hepatic encephalopathy (MHE) using T2relaxometry and to correlate T2values with brain metabolites evaluated using 2D magnetic resonance spectroscopy (MRS).Materials and MethodsEight MHE patients and 13 healthy subjects were evaluated using T2relaxometry, and eight patients and nine healthy subjects underwent 2D MRS in right frontal and left occipital regions. Whole‐brain T2‐relaxation maps were compared between MHE and control subjects using analysis‐of‐covariance, with age and gender included as covariates. T2values derived from the right frontal and left occipital lobes were correlated with the metabolite ratios.ResultsMultiple brain regions including anterior and mid cingulate cortices, right anterior and left posterior insular cortices, right prefrontal, medial frontal, and right superior temporal cortices showed significantly increased T2values in MHE patients compared to control subjects. MRS showed significantly increased ratios of glutamine/glutamate (Glx) and decreased ratios of myo‐inositol, taurine, choline, and myo‐inositol/choline (mICh) with respect to creatine (Cr_d) in patients compared to controls. Frontal Glx/Cr_d showed significantly positive correlation with T2values.ConclusionMHE patients showed significantly increased T2values in multiple brain regions reflecting increased free water content and T2values in frontal lobe correlated with the increased Glx/Cr_d ratio. J. Magn. Reson. Imaging 2009;30:1034–1041. © 2009 Wiley‐Liss, Inc.
