Central neuromechanisms underlying control of intragastric pressure through acupuncture at Zusanli (ST36) in rats: the upper cervical cord is the key link between the ascending and descending pathways.
Central neuromechanisms underlying control of intragastric pressure through acupuncture at Zusanli (ST36) in rats: the upper cervical cord is the key link between the ascending and descending pathways.
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DOI：
10.4103/1673-5374.184497
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发表时间：
2016-06
影响因子：
6.1
通讯作者：
Li JS
中科院分区：
文献类型：
--
作者：
Yong CY;Chen S;Chen H;Chu X;Zhang C;Tan C;Ye L;Li JS
众所周知，腹部足三里（ST 36）针刺刺激的感觉输入会集中在上颈髓。然而，目前还不清楚这些输入是否随后被传递到下丘脑室旁核，以及涉及什么样的传入纤维。我们专注于上颈髓，传入输入汇聚，并检测c-fos的催产素能神经元的表达。结果表明，针刺足三里穴能有效地提高上颈髓损伤大鼠胃内压，但抑制室旁核催产素能神经元c-fos的表达。这些足三里针刺效应仍然存在，即使在完全背侧脊髓横断。但脊髓或背外侧索完全切断后，这种效应明显减弱甚至消失。这些结果表明，室旁核负责汇集和整合来自足三里针刺的信号和来自胃内压力变化的感觉信息，从而有助于调节胃内压力。上颈髓是上行通路和下行通路之间的关键环节，通过背外侧索将传入信息传递到室旁核。
Sensory inputs stimulated by Zusanli (ST36) acupuncture in the abdomen are known to converge in the upper cervical cord. However, it is unclear whether these inputs are subsequently conveyed to the hypothalamic paraventricular nucleus and what kind of afferent fibers are involved. We focused on the upper cervical cord, where afferent inputs converge, and detected c-fos expression in oxytocinergic neurons. We found that Zusanli acupuncture therapy effectively elevated intragastric pressure, but inhibited expression of c-fos in oxytocinergic neurons of the paraventricular nucleus in upper cervical cord injured rats. These Zusanli acupuncture effects remained even after complete dorsal cord transection. However, after complete transection of the spinal cord or dorsolateral funiculus, the effects were significantly attenuated and even disappeared. These findings suggest that the paraventricular nucleus is responsible for pooling and integrating signals from the Zusanli acupuncture and sensory information from the intragastric pressure variation, thereby contributing to the regulation of intragastric pressure. The upper cervical cord serves as the key link between ascending and descending pathways, which conveys afferent inputs to the paraventricular nucleus through the dorsolateral funiculus.