Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine
Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine
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DOI：
10.1016/j.etap.2007.04.008
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发表时间：
2007-09-01
影响因子：
4.3
通讯作者：
Hedge, Joan M.
中科院分区：
文献类型：
--
作者：
Crofton, Kevin M.;Paul, Katie B.;Hedge, Joan M.
三氯生(5-氯-2-(2，4-二氯苯氧基)苯酚)是一种氯化酚类抗菌化合物，在许多个人护理和家居产品中发现作为活性成分。三氯生的结构与甲状腺激素相似，最近的研究表明，人孕烷X受体(PXR)被激活，二碘甲状腺原氨酸(T-2)磺基转移酶被抑制，这引起了人们对甲状腺动态平衡的不利影响的担忧。目前的研究验证了三氯生改变甲状腺激素循环浓度的假设。对断奶的雌性Long-Evans大鼠口服三氯生4天(0-1000 mg/kg/天)，然后测量循环中血清总甲状腺激素(T-4)的水平，以检验这一假设。总T4呈剂量依赖性下降。对T4影响的基准剂量(BMD)为69.7 mg/kg/d，骨密度下限(BMDL)为35.6 mg/kg/d。这些数据表明，三氯生破坏了大鼠甲状腺激素的稳态。(C)2007 Elsevier B.V.保留所有权利。
Triclosan (5-chioro-2-(2,4-dichlorophenoxy)phenol) is a chlorinated phenolic antibacterial compound found as an active ingredient in many personal care and household products. The structural similarity of triclosan to thyroid hormones and recent studies demonstrating activation of the human pregnane X receptor (PXR) and inhibition of diiodothyronine (T-2) sulfotransferases, have raised concerns about adverse effects on thyroid homeostasis. The current research tested the hypothesis that triclosan alters circulating concentrations of thyroxine. The hypothesis was tested using a 4-day oral triclosan exposure (0-1000 mg/kg/day) in weanling female Long-Evans rats, followed by measurement of circulating levels of serum total thyroxine (T-4). Dose-dependent decreases in total T4 were observed. The benchmark dose (BMD) and lower bound on the BMD (BMDL) for the effects on T4 were 69.7 and 35.6 mg/kg/day, respectively. These data demonstrate that triclosan disrupts thyroid hormone homeostasis in rats. (c) 2007 Elsevier B.V. All rights reserved.