Psychopathology in adults with 22q11 deletion syndrome and moderate and severe intellectual disability
Psychopathology in adults with 22q11 deletion syndrome and moderate and severe intellectual disability
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DOI：
10.1111/jir.12117
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发表时间：
2014-10-01
影响因子：
3.6
通讯作者：
Curfs, L. M. G.
中科院分区：
文献类型：
--
作者：
Evers, L. J. M.;van Amelsvoort, T. A. M. J.;Curfs, L. M. G.
背景 22q11 缺失综合征 (22q11DS) 与轻度或边缘性智力障碍 (ID) 相关。几乎没有关于患有中度或重度智力障碍的 22q11DS 受试者的报道，因此其行为和精神特征尚不清楚。方法我们描述了 33 名 22q11DS 且满量程智商（FSIQ）低于 55 的成年人的行为和精神特征。参与者被分为两组：一组具有由智力下降引起的 FSIQ55（n = 21），另一组具有 FSIQ55，但一直在这个水平（n = 12）。结果两个亚组的精神病理学子量表得分都很高。智力下降的 22q11DS 患者表现出较高的共病精神病理学率，尤其是精神病。此外，精神病和智力下降呈正相关。结论这是第一份针对 22q11DS 和中重度智力障碍成年患者的报告。总体而言，我们发现智力下降组的精神病理学水平较高，精神病理学得分较高。终生精神病似乎与病情恶化有关。
Background22q11 deletion syndrome (22q11DS) is associated with mild or borderline intellectual disability (ID). There are hardly any reports on subjects with 22q11DS with moderate or severe ID, and therefore its behavioural and psychiatric characteristics are unknown.MethodWe describe behavioural and psychiatric characteristics of 33 adults with 22q11DS and a Full-Scale IQ (FSIQ) below 55. Participants were divided into two groups: one group having a FSIQ55 caused by intellectual decline (n=21) and one group with a FSIQ55 who had always functioned at this level (n=12).ResultsHigh scores on psychopathology sub-scales were found for both subgroups. 22q11DS patients with intellectual decline showed higher rates of co-morbid psychopathology, particularly psychosis. Furthermore, psychosis and intellectual decline were positive correlated.ConclusionThis is the first report addressing adult patients with 22q11DS and moderate to severe ID. Overall we found high levels of psychopathology with higher scores of psychopathology in the intellectual decline group. Life time psychosis seems to be related to deterioration.