Corticofugal Control of Vibrissa-Sensitive Neurons in the Interpolaris Nucleus of the Trigeminal Complex
Corticofugal Control of Vibrissa-Sensitive Neurons in the Interpolaris Nucleus of the Trigeminal Complex
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DOI：
10.1523/jneurosci.4274-09.2010
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发表时间：
2010-02-03
影响因子：
5.3
通讯作者：
Deschenes, Martin
中科院分区：
文献类型：
--
作者：
Furuta, Takahiro;Urbain, Nadia;Deschenes, Martin
产生振动信息上升通路的三叉神经感觉核与亚核间的连接紧密相连。例如，三叉主核就是这种情况，它接受来自内插亚核尾侧的强抑制性输入。由于这种抑制性输入可以抑制感觉信息的传递，因此振动生理学的一个中心问题是，投射到内插的大脑区域如何控制抑制性细胞的活动。在本研究中，我们研究了初级和第二体感皮层皮质三叉神经如何控制内插细胞的兴奋性。结果表明，这两个皮层区域对投射细胞和亚核间中间神经元的兴奋性有不同的控制，这种控制还涉及尾侧亚核抑制细胞的募集。这些结果提供了一个基本的电路机制的解除抑制，通过该机制，大脑皮层可以控制感官信息的传递在lemiscal通路。我们提出，自上而下的脑干回路控制是由动物的运动策略、期望和动机状态所推动的。
Trigeminal sensory nuclei that give rise to ascending pathways of vibrissal information are heavily linked by intersubnuclear connections. This is the case, for instance, of the principal trigeminal nucleus, which receives strong inhibitory input from the caudal sector of the interpolaris subnucleus. Because this inhibitory input can gate the relay of sensory messages through the lemniscal pathway, a central issue in vibrissal physiology is how brain regions that project to the interpolaris control the activity of inhibitory cells. In the present study, we examined how corticotrigeminal neurons of the primary and second somatosensory cortical areas control the excitability of interpolaris cells. Results show that these two cortical areas exert a differential control over the excitability of projection cells and intersubnuclear interneurons, and that this control also involves the recruitment of inhibitory cells in the caudalis subnucleus. These results provide a basic circuitry for a mechanism of disinhibition through which the cerebral cortex can control the relay of sensory messages in the lemniscal pathway. It is proposed that top-down control of brainstem circuits is prompted by motor strategies, expectations, and motivational states of the animal.