A case-control study of large bowel cancer in Japan.
A case-control study of large bowel cancer in Japan.
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日本大肠癌的病例对照研究。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
M. Segi
中科院分区：
文献类型：
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作者：
W. Haenszel;F. Locke;M. Segi
这项关于饮食和其他环境因素的调查报告了日本三个县的588名结直肠癌患者和1，176名住院对照。弱（统计上不显着）的积极影响，发现社会阶层和城市化。先前在夏威夷日本人中描述的结直肠癌与牛肉、菜豆或淀粉消费的显著相关性在这里没有重现。与hakusal（卷心菜）的协会同意与十字花科蔬菜的负面协会的其他报告。对低位直肠病例子集的分析得出的结果与整个系列的结果相似。在日本未能发现重要的食物效应是由于在饮食习惯相同的地区难以检测病例对照差异。进一步的流行病学研究，在正在进行的动物研究的帮助下，可能会为更明确的问题提供思路，应该强调更准确的饮食史的新方法，并应继续强调肿瘤定位。
This investigation of diet and other environmental factors reports on 588 patients with colorectal cancer and 1,176 hospitalized controls in three prefectures of Japan. Weak (not statistically significant) positive effects were found for social class and urbanization. The significant association of colorectal cancer with consumption of beef, string beans, or starches previously described for Hawaiian Japanese were not reproduced here. An association with hakusal (cabbage) agreed with other reports on a negative association with cruciferous vegetables. An analysis of the subset of cases in the low rectum yielded results similar to those for the total series. The failure to uncover important food effects in Japan is attributed to the difficulty of detecting case-control differences in areas with homogeneous diet practices. Further epidemiologic research aided by leads from ongoing work with animals may provide ideas for more sharply defined questions, should stress new approaches for more accurate diet histories, and should continue to emphasize tumor localization.