Liver X receptor α-dependent iron handling in M2 macrophages: The missing link between cholesterol and intraplaque hemorrhage?
Liver X receptor α-dependent iron handling in M2 macrophages: The missing link between cholesterol and intraplaque hemorrhage?
复制标题
M2巨噬细胞中肝脏X受体α依赖性铁处理：胆固醇和斑块内出血之间缺失的联系？
DOI：
10.1161/circresaha.113.302613
复制
发表时间：
2013
影响因子：
20.1
通讯作者：
Yvan-Charvet,Laurent
中科院分区：
文献类型：
--
作者：
Hasty,AlyssaH;Yvan-Charvet,Laurent
Hasty and Yvan-Charvet LXRα, Macrophage Iron Handling and Atherosclerosis 1183 human atherosclerotic plaques. Thus, it will be of interest to further characterize whether other macrophage subpopulations preferentially accumulate iron in human atherosclerotic plaques. Furthermore, as speculated by the authors, a change in the ratio of MR+CD163+ and MR+CD163− may occur during plaque progression as a result of higher or recurrent exposure to senescent erythrocytes containing iron. Clearly, the study of Bories et al1 provides an important step in translational atherosclerosis research by functionally characterizing human atherosclerotic plaque M2 polarized macrophages. Furthermore, their earlier work demonstrated the possibility of promising therapeutic opportunities to diagnose and treat human atherosclerosis.
