Evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight
Evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight
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DOI：
10.3109/00016357.2012.697576
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发表时间：
2013-05-01
影响因子：
2
通讯作者：
Akincibay, Hakan
中科院分区：
文献类型：
--
作者：
Ercan, Esra;Eratalay, Kenan;Akincibay, Hakan
背景资料。早产和/或低出生体重(PTLBW)是发展中国家的一个严重问题。在类似于50%的PTLBW病例中，由于缺乏已知的危险因素，导致继续寻找其他原因。本研究的目的是研究牙周炎对妊娠结局的影响。方法：研究方法。样本取自50名接受羊膜穿刺术的孕妇。对羊膜穿刺术中采集的羊水标本和龈下菌斑标本进行聚合酶链式反应，检测牙龈卟啉单胞菌、伴生放线杆菌、齿密螺旋体、连翘杆菌、核梭杆菌、中间普氏杆菌、直肠弯曲杆菌和腐蚀性艾肯氏杆菌。评价菌斑指数、牙龈指数、探诊出血量、探诊深度和临床附着水平。医疗记录是在出生后获得的。结果。牙周炎(G)组、局限性牙周炎(LP)组和泛发性牙周炎(GP)组之间的社会和人口学变量相似。4名受试者生下了PTLBW新生儿。在3例PTLBW患儿的羊水和龈下菌斑标本中检出直肠弯曲杆菌、连翘杆菌、牙龈弯曲菌和核弯曲菌。第四名患者的羊水样本对任何检测的病原体都不呈阳性。结论。这些发现表明，一些牙周病原体从母亲的口腔传播可能会导致不良的妊娠结局。这些结果有助于理解牙周病和PTLBW之间的联系，但需要进一步的研究来更好地阐明可能的关系。
Background. Pre-term birth and/or low birth weight (PTLBW) is a serious problem in developing countries. The absence of known risk factors in similar to 50% of PTLBW cases has resulted in a continued search for other causes. The aim of this study was to examine the effect of periodontitis on pregnancy outcomes. Methods. Samples were taken from 50 pregnant women who underwent amniocentesis. Polymerase chain reaction was performed on amniotic fluid samples obtained during amniocentesis and on subgingival plaque samples to determine the presence of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedia, Campylobacter rectus and Eikenella corrodens. Plaque index, gingival index, bleeding on probing, probing depth and clinical attachment level were evaluated. Medical records were obtained after birth. Results. Social and demographic variables were similar among the Gingivitis (G), Localized Periodontitis (LP) and Generalized Periodontitis (GP) groups. Four subjects gave birth to PTLBW neonates. Campylobacter rectus, T. forsythia, P. gingivalis and F. nucleatum were detected in the amniotic fluid and subgingival plaque samples of three patients who gave birth to PTLBW neonates. The amniotic fluid sample from the fourth patient was not positive for any of the tested pathogens. Conclusion. These findings suggest that the transmission of some periodontal pathogens from the oral cavity of the mother may cause adverse pregnancy outcomes. The results contribute to an understanding of the association between periodontal disease and PTLBW, but further studies are required to better clarify the possible relationship.