Crohn's disease
Crohn's disease
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DOI：
10.1016/s0140-6736(02)07284-7
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发表时间：
2002-01-05
期刊：
影响因子：
168.9
通讯作者：
Shanahan, F
中科院分区：
文献类型：
--
作者：
Shanahan, F
克罗恩病是一种由T淋巴细胞介导的疾病，其在遗传易感个体中由于对肠道细菌的粘膜免疫应答的调节约束的破坏而出现。对肠道抗原的免疫反应性的调节提高了对克罗恩病的病理生理机制的理解，并扩大了患有这种疾病的患者的治疗选择。可能存在疾病异质性，存在与相似病理生理学结局相关的各种潜在缺陷。尽管大多数常规药物治疗都是针对宿主反应的改变，但对肠道植物群的治疗操作正在成为一种现实的选择。
Crohn's disease is a disorder mediated by T lymphocytes which arises In genetically susceptible Individuals as a result of a breakdown in the regulatory constraints on mucosal immune responses to enteric bacteria, Regulation of Immune reactivity to enteric antigens has improved understanding of the pathophysiological mechanisms of Crohn's disease, and has expanded therapeutic options for patients with this disorder. Disease heterogeneity Is probable, with various underlying defects associated with a similar pathophysiological outcome. Although most conventional drug treatments are directed at modification of host response, therapeutic manipulation of the enteric flora Is becoming a realistic option.