Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential.
Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential.
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DOI：
10.3389/fcvm.2018.00006
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发表时间：
2018
影响因子：
3.6
通讯作者：
Jain MK
中科院分区：
文献类型：
--
作者：
Sweet DR;Fan L;Hsieh PN;Jain MK
炎症在血管疾病中的作用是公认的，它涉及循环免疫细胞和血管壁细胞本身的失调。无节制的血管炎症导致病理重塑，最终导致动脉粥样硬化性血栓疾病及其相关的后遗症(例如，心肌/脑梗塞、栓塞和严重的肢体缺血)。血管炎症过程中的信号事件协调广泛的转录程序，影响血管和循环炎症细胞的功能。Krüppel样因子(KLF)是一类转录因子家族，在体内稳态和疾病状态下调节血管生物学起重要作用。鉴于它们在与血管炎症相关的细胞中的丰富性和功能的多样性，了解KLF调控的转录网络将促进我们对几种普遍存在的健康问题(如动脉粥样硬化、中风等)的发病机制的理解。从而为心血管疾病的治疗提供信息。在这篇综述中，我们将讨论KLF在协调血管炎症期间保护性和有害反应中的作用，同时解决这些关键转录因子在未来治疗中的潜在靶向。
The role of inflammation in vascular disease is well recognized, involving dysregulation of both circulating immune cells as well as the cells of the vessel wall itself. Unrestrained vascular inflammation leads to pathological remodeling that eventually contributes to atherothrombotic disease and its associated sequelae (e.g., myocardial/cerebral infarction, embolism, and critical limb ischemia). Signaling events during vascular inflammation orchestrate widespread transcriptional programs that affect the functions of vascular and circulating inflammatory cells. The Krüppel-like factors (KLFs) are a family of transcription factors central in regulating vascular biology in states of homeostasis and disease. Given their abundance and diversity of function in cells associated with vascular inflammation, understanding the transcriptional networks regulated by KLFs will further our understanding of the pathogenesis underlying several pervasive health concerns (e.g., atherosclerosis, stroke, etc.) and consequently inform the treatment of cardiovascular disease. Within this review, we will discuss the role of KLFs in coordinating protective and deleterious responses during vascular inflammation, while addressing the potential targeting of these critical transcription factors in future therapies.