Effects of alpha-MSH on sleep, behavior, and brain temperature: interactions with IL 1.
Effects of alpha-MSH on sleep, behavior, and brain temperature: interactions with IL 1.
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α-MSH 对睡眠、行为和脑温度的影响：与 IL 1 的相互作用。
DOI：
10.1152/ajpregu.1988.255.6.r914
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Krueger,JM
中科院分区：
文献类型：
--
作者：
Opp,MR;ObalJr,F;Krueger,JM
研究了侧脑室注射一种假定的内源性解热剂α-黑素细胞刺激激素（α-MSH）和一种内源性致热原白细胞介素1（IL 1-β）后家兔睡眠-觉醒活动、脑温（Tbr）和行为的变化。α-MSH（0.1-50.0微克）剂量依赖性地增加觉醒（W）和减少Tbr、非快速眼动睡眠（NREMS）和快速眼动睡眠（REMS）。NREMS比REMS对低α-MSH剂量的抑制作用更敏感。α-MSH治疗后NREMS的EEG慢波活动减少。α-MSH引起伸展、打哈欠和性兴奋的迹象。IL 1（20和40 ng）诱导发热和过度NREMS。在IL 1后30分钟给予α-MSH（40或20 ng IL 1 + 0.1、0.5或5.0微克α-MSH）显著减弱IL 1诱导的发热和过度NREMS。IL 1不能改变α-MSH的行为效应。尽管α-MSH对兔行为有影响，但总运动活动时间并没有增加，表明α-MSH后W的增加不能归因于行为激活。这些结果表明，除了作为一种内源性解热剂，α-MSH可能参与调节IL 1诱导的睡眠。
Changes in rabbit sleep-wake activity, brain temperature (Tbr), and behavior were studied after intracerebroventricular injections of a putative endogenous antipyretic, alpha-melanocyte-stimulating hormone (alpha-MSH), and of an endogenous pyrogen, interleukin 1 (IL 1-beta). alpha-MSH (0.1-50.0 micrograms) dose dependently increased wakefulness (W) and decreased Tbr, non-rapid-eye-movement sleep (NREMS), and rapid-eye-movement sleep (REMS). NREMS was more sensitive than REMS to the suppressive effects of low alpha-MSH doses. EEG slow-wave activity in NREMS decreased after alpha-MSH treatment. alpha-MSH elicited stretching, yawning, and signs of sexual excitation. IL 1 (20 and 40 ng) induced fever and excess NREMS. alpha-MSH administered 30 min after IL 1 (40 or 20 ng IL 1 + 0.1, 0.5, or 5.0 micrograms alpha-MSH) significantly attenuated IL 1-induced fever and excess NREMS. IL 1 failed to alter the behavioral effects of alpha-MSH. Despite alpha-MSHs effect on rabbit behavior, total motor activity time did not increase, indicating that increased W after alpha-MSH cannot be attributed to behavioral activation. These results suggest that, besides acting as an endogenous antipyretic, alpha-MSH might be involved in regulation of IL 1-induced sleep.