Clinicopathological characteristics and perineural invasion in adenoid cystic carcinoma: a systematic review.
Clinicopathological characteristics and perineural invasion in adenoid cystic carcinoma: a systematic review.
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DOI：
10.1016/j.bjorl.2014.07.016
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发表时间：
2015-05
影响因子：
2.2
通讯作者：
中科院分区：
文献类型：
--
作者：
腺样囊性癌是下颌下腺和小涎腺最常见的恶性肿瘤。它是一种恶性肿瘤，尽管生长缓慢，但预后不良。本研究的目的是对头颈部腺样囊性癌及其临床病理特征的文献进行系统回顾，重点是肿瘤的神经浸润能力。在PubMed/MEDLINE、SciELO、Science Direct和Scopus数据库中对2000年1月至2014年1月期间发表的文章进行了系统检索。本次系统性综述共选择了9篇文章。这些结果表明，女性更常受到影响，恶性肿瘤显示出高的远处转移率、复发率和低的生存率。神经周围浸润的发生率为29.4%~ 62.5%，与局部肿瘤复发有关。腺样囊性癌通常以疼痛、高复发率、高转移率和低生存率为特征。报告患者随访研究对于更好地理解临床病理学和改善这种病理学的预后至关重要。
Adenoid cystic carcinoma is the most frequent malignant tumor of the submandibular gland and the minor salivary glands. It is a malignant neoplasm that, despite its slow growth, shows an unfavorable prognosis. The aim of this study was to perform a systematic review of the literature on Adenoid cystic carcinoma in the head and neck region and its clinicopathological characteristics, with emphasis on the perineural invasion capacity of the tumor. A systematic search of articles published between January 2000 and January 2014 was performed in the PubMed/MEDLINE, SciELO, Science Direct, and Scopus databases. Nine articles were selected for this systematic review. These demonstrated that the female gender was more often affected and that malignant tumors showed a high rate of distant metastasis, recurrence, and a low survival rate. The presence of perineural invasion ranged from 29.4% to 62.5% and was associated with local tumor recurrence. Adenoid cystic carcinoma is commonly characterized by the presence of pain, high rate of recurrence, metastasis, and a low survival rate. Reporting studies with patient follow-up is of utmost importance for a better clinical-pathological understanding and to improve the prognosis of this pathology.