Breathing with Phox2b
Breathing with Phox2b
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DOI：
10.1098/rstb.2009.0085
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发表时间：
2009-09-12
影响因子：
6.3
通讯作者：
Brunet, Jean-Francois
中科院分区：
文献类型：
--
作者：
Dubreuil, Veronique;Barhanin, Jacques;Brunet, Jean-Francois
在过去的几年里，呼吸控制中心的结构的阐明已经达到了细胞水平。这已经通过增加对各种类别的后脑神经元的分子特征的了解而得到促进。在这里，我们回顾了通过研究同源结构域因子Phox2b，在中枢和外周神经系统的神经元身份的转录决定因素所取得的进展。来自人类遗传学、神经生理学和小鼠反向遗传学的证据表明，位于后斜方核中的一小群Phox2b依赖性神经元参与了CO2的检测，这是“驱动呼吸”的最重要来源。此外，相同的和其他的研究表明，重叠或相同的神经元群体，parasfacial呼吸组，可能有助于呼吸节律至少在某些情况下，如出生后的呼吸开始。加上之前建立的其他呼吸神经元的Phox 2b依赖性（我们在这里简要回顾），我们的新数据强调了这种转录因子在建立呼吸自动性回路中的关键作用。
In the last few years, elucidation of the architecture of breathing control centres has reached the cellular level. This has been facilitated by increasing knowledge of the molecular signatures of various classes of hindbrain neurons. Here, we review the advances achieved by studying the homeodomain factor Phox2b, a transcriptional determinant of neuronal identity in the central and peripheral nervous systems. Evidence from human genetics, neurophysiology and mouse reverse genetics converges to implicate a small population of Phox2b-dependent neurons, located in the retrotrapezoid nucleus, in the detection of CO2, which is a paramount source of the 'drive to breathe'. Moreover, the same and other studies suggest that an overlapping or identical neuronal population, the parafacial respiratory group, might contribute to the respiratory rhythm at least in some circumstances, such as for the initiation of breathing following birth. Together with the previously established Phox2b dependency of other respiratory neurons (which we review briefly here), our new data highlight a key role of this transcription factor in setting up the circuits for breathing automaticity.