Dietary patterns and adult asthma: population-based case-control study
Dietary patterns and adult asthma: population-based case-control study
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DOI：
10.1111/j.1398-9995.2009.02215.x
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发表时间：
2010-05-01
期刊：
影响因子：
12.4
通讯作者：
Shaheen, S. O.
中科院分区：
文献类型：
--
作者：
Bakolis, I.;Hooper, R.;Shaheen, S. O.
背景：关于饮食和哮喘的流行病学研究主要集中在个人营养和食物摄入量的关系上，而证据一直相互矛盾。很少有研究考察与饮食模式的关系。方法：我们在英国伦敦南部对16岁至50岁的成年人进行了一项基于人群的病例对照研究。通过食物频度问卷获得有关日常饮食的信息，并用主成分分析进行分析。对照组的五种饮食模式。结果：总体上，没有证据表明‘素食’饮食模式与哮喘正相关[调整后的优势比与模式得分的上下五分之一比较，P趋势0.075]，而‘传统’饮食模式(肉类和蔬菜)负相关[OR0.68(0.45-1.03)，P趋势0.071]。这些关联性在非补充剂使用者中更强(P趋势分别为0.030和0.001)，而在白人中与素食模式的关联性更强(P趋势0.008)。没有观察到与哮喘严重程度相关。谨慎的饮食结构(全麦面包、鱼和蔬菜)与慢性支气管炎呈正相关[OR2.61(1.13-6.05)，P趋势0.025]，尤其是在非补充剂使用者中(P趋势0.002)。结论：总体来说，饮食结构与成人哮喘之间没有明确的关系；非补充剂使用者和白人之间的关联有待证实。慢性支气管炎的发现是出乎意料的，也需要复制。
Background: Epidemiological studies of diet and asthma have focused on relations with intakes of individual nutrients and foods and evidence has been conflicting. Few studies have examined associations with dietary patterns.Methods: We carried out a population-based case-control study of asthma in adults aged between 16 and 50 in South London, UK. Information about usual diet was obtained by food frequency questionnaire and we used principal components analysis to de. ne five dietary patterns in controls. We used logistic and linear regression, controlling for confounders, to relate these patterns to asthma, asthma severity, rhinitis and chronic bronchitis in 599 cases and 854 controls.Results: Overall, there was weak evidence that a 'vegetarian' dietary pattern was positively associated with asthma [adjusted odds ratio comparing top vs bottom quintile of pattern score 1.43 (95% CI: 0.93-2.20), P trend 0.075], and a 'traditional' pattern (meat and vegetables) was negatively associated [OR 0.68 (0.45-1.03), P trend 0.071]. These associations were stronger amongst nonsupplement users (P trend 0.030 and 0.001, respectively), and the association with the 'vegetarian' pattern was stronger amongst whites (P trend 0.008). No associations were observed with asthma severity. A 'prudent' dietary pattern (wholemeal bread,fish and vegetables) was positively associated with chronic bronchitis [OR 2.61 (1.13-6.05), P trend 0.025], especially amongst nonsupplement users (P trend 0.002).Conclusions: Overall there were no clear relations between dietary patterns and adult asthma; associations in nonsupplement users and whites require confirmation. The finding for chronic bronchitis was unexpected and also requires replication.