Tamm-Horsfall protein excretion and its relation to citrate in urine of stone-forming patients
Tamm-Horsfall protein excretion and its relation to citrate in urine of stone-forming patients
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DOI：
10.1016/s0090-4295(98)00581-0
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发表时间：
1999-03-01
期刊：
影响因子：
2.1
通讯作者：
Hesse, A
中科院分区：
文献类型：
--
作者：
Ganter, K;Bongartz, D;Hesse, A
目标.探讨Tamm-Horsfall蛋白（THP）和柠檬酸盐在尿结石形成过程中的作用。采用酶联免疫吸附法（ELISA）对草酸钙（CaOx）结石患者和健康人血清中THP进行定量测定。与健康受试者相比，CaOx结石形成患者24小时尿液样本中的THP排泄显著减少。在结石形成组以及健康受试者组中，THP和柠檬酸盐浓度之间存在显着相关性，并且对于24小时排泄，这种相关性在CaOx结石形成患者组中持续存在。结论。在CaOx结石形成患者中发现THP和柠檬酸盐排泄减少。它们表明远端部分的肾小管功能障碍。(C)1999年，Elsevier Science Inc. All rights reserved.
Objectives. To evaluate the relation of Tamm-Horsfall protein (THP) and citrate, both potent actors in the urinary stone forming process.Methods. Quantitative determination of THP in calcium oxalate (CaOx) stone-forming patients and healthy subjects was carried out according to the enzyme-linked immunosorbent assay method.Results. THP excretion in 24-hour urine samples of CaOx stone-forming patients was significantly reduced compared with healthy subjects. A significant correlation exists between the concentration of THP and citrate in the stone-forming group, as well as in the group of healthy subjects, and for the 24-hour excretion, this correlation persists in the group of CaOx stone-forming patients.Conclusions. Decreased THP and citrate excretions were found in CaOx stone-forming patients. They indicate a tubular dysfunction of the distal section. (C) 1999, Elsevier Science Inc. All rights reserved.