SECONDARY STRUCTURE PREDICTIONS AND MEDIUM RANGE INTERACTIONS
SECONDARY STRUCTURE PREDICTIONS AND MEDIUM RANGE INTERACTIONS
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DOI：
10.1016/0167-4838(87)90109-9
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发表时间：
1987-11-26
期刊：
影响因子：
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通讯作者：
LOUGHRAN, S
中科院分区：
文献类型：
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作者：
WILLIAMS, RW;CHANG, A;LOUGHRAN, S
几位作者提出，如果包含参与中短期相互作用的邻近残基的信息，那么根据已知结构的统计信息可以改进对蛋白质二级结构的预测。此处显示的实质性改进表明，当前包含此信息的方法并不比不包含此信息的方法更成功。对Chou和Fasman方法的评价(Adv.Enzymol.47(1978)45-148)，这不包括关于相互作用的信息(平均除外)，已经表明对于三种状态(螺旋、β-折叠和未定义)，其准确率约为49%。相比之下，Garnier等人的方法。(J.Mol.比奥尔。120(1978)97-120)，明确包括关于邻近残基的信息，对于三个州具有57%的残基准确率。然而，基于Chou和Fasman的算法，我们在二级结构预测上获得了8%的改进。改进是通过消除许多规则和从结构分配中选择最佳决策常量来实现的。使用1978年计算的偏好值，这里描述的简化方法对三个州的准确率为57%。
Several authors have proposed that predictions of protein secondary structure derived from statistical information about the known structures can be improved when information about neighboring residues participating in short and medium range interactions is included. A substantial improvement shown here indicates that current methods of including this information are not more successful than methods that do not. Evaluations of the Chou and Fasman method (Adv. Enzymol. 47 (1978) 45-148), that does not include information about interactions (except in averaging), have shown it to be about 49% correct for three states (helix, .beta.-sheet and undefined). In comparison, the method of Garnier et al. (J. Mol. Biol. 120 (1978) 97-120), that explicitly includes information about neighboring residues, has an accuracy of 57% residues correct for three states. However, we have obtained an 8% improvement for predictions of secondary structure based on the algorithm by Chou and Fasman. The improvements are obtained by eliminating many rules and by choosing the best decision constants from structure assignments. The simplified method described here is 57% correct for three states using preference values calculated in 1978.