Contrasting grooming phenotypes in three mouse strains markedly different in anxiety and activity (129S1, BALB/c and NMRI)
Contrasting grooming phenotypes in three mouse strains markedly different in anxiety and activity (129S1, BALB/c and NMRI)
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DOI：
10.1016/j.bbr.2004.11.010
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发表时间：
2005-05-07
影响因子：
2.7
通讯作者：
Tuohimaa, P
中科院分区：
文献类型：
--
作者：
Kalueff, AV;Tuohimaa, P
129S1/SvImJ(129S1)、NMRI和BALB/c小鼠被广泛应用于行为学研究，表现出明显的品系差异。在啮齿动物的行为中，梳理毛发是一个复杂而基本的仪式，伴随着一个一般的头尾进展(前爪-鼻子-脸-身体-腿-尾巴和生殖器)。据报道，各种应激源以及基因操作都会改变小鼠的毛发及其模式，这表明分析毛发行为的重要性。尽管在许多研究中已经评估了这些小鼠之间的品系差异，但还没有对它们的美容进行比较分析。在这里，我们展示了129S1、NMR1和BALB/c小鼠在自发(新奇诱导)梳理方面的品系差异。总体而言，129S1小鼠表现出较低的梳理活动和微结构受损(更多的间歇发作和与头尾规则相反的错误过渡)，并伴随着较低的垂直探索。相比之下，BALB/c和NMRI小鼠表现出高度的垂直活动和未受损的梳理微结构，也表现出不同的梳理水平(BALB/c>；NMRI)。我们的研究表明，这些小鼠不同的梳理表型可能不是由于它们在感觉能力、一般活动水平、脑解剖或攻击性方面的品系差异，而是反映了这些品系中焦虑、运动和位移活动之间的复杂相互作用(129S1小鼠的低活动焦虑表型，BALB/c小鼠的活跃焦虑表型和NMRI小鼠的非焦虑高置换表型)。我们认为，对小鼠毛发的行为学分析，如这里所报道的，可能是神经行为研究中的有用工具。©2004爱思唯尔B.V.保留所有权利。
129S1/SvImJ (129S1), NMRI and BALB/c mice are widely used in behavioural research, demonstrating marked strain differences in their behavioural phenotypes. Grooming is a complex and essential ritual in the rodent behavioural repertoire with a general cephalocaudal progression (forepaws-nose-face-body-legs-tail and genitals). Various stressors as well as genetic manipulations have been reported to alter mouse grooming and its patterning, underlying the importance of analysis of grooming behaviours. Although strain differences between these mice have been assessed in many studies, no comparative analyses of their grooming have been performed. Here we show strain differences in spontaneous (novelty-induced) grooming between 129S1, NMR1 and BALB/c mice. Overall, 129S1 mice demonstrated lower grooming activity and impaired microstructure (more interrupted bouts and incorrect transitions contrary to the cephalocaudal rule), accompanied by lower vertical exploration. In contrast, BALB/c and NMRI mice showed high vertical activity and unimpaired grooming microstructure, also exhibiting different grooming levels (BALB/c > NMRI). Our study suggests that contrasting grooming phenotypes in these mice may not be due to the strain differences in their sensory abilities, general activity levels, brain anatomy or aggressiveness, but rather reflect a complex interplay between anxiety, motor and displacement activity in these strains (hypoactive anxious phenotype in 129S1 mice, active anxious phenotype in BALB/c and non-anxious high displacement phenotype in NMRI mice). We suggest that ethological analysis of mouse grooming, such as that reported here, may be a useful tool in neurobehavioural research. © 2004 Elsevier B.V. All rights reserved.