A CELL-SURFACE MOLECULE INVOLVED IN ORGAN-SPECIFIC HOMING OF LYMPHOCYTES
A CELL-SURFACE MOLECULE INVOLVED IN ORGAN-SPECIFIC HOMING OF LYMPHOCYTES
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DOI：
10.1038/304030a0
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发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
BUTCHER, EC
中科院分区：
文献类型：
--
作者：
GALLATIN, WM;WEISSMAN, IL;BUTCHER, EC
淋巴细胞通过识别并结合淋巴结和派尔集合淋巴结中的高内皮微静脉（HEV）内衬的特化内皮细胞而从血流中迁移。我们在这里描述的单克隆抗体，MEL-14，特异性的淋巴细胞表面分子，似乎介导的识别淋巴结戊型肝炎病毒，并需要淋巴细胞归巢到淋巴nodesin体内。
Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodesin vivo.