COMPARISON OF ACYLCARNITINES AND PYRUVATE AS SUBSTRATES FOR RAT-LIVER MITOCHONDRIA
COMPARISON OF ACYLCARNITINES AND PYRUVATE AS SUBSTRATES FOR RAT-LIVER MITOCHONDRIA
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DOI：
10.1016/0005-2760(66)90087-7
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发表时间：
1966-01-01
期刊：
影响因子：
--
通讯作者：
BREMER, J
中科院分区：
文献类型：
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作者：
BREMER, J
在大鼠肝线粒体中比较了 L-癸基肉碱、L-棕榈基肉碱和丙酮酸的氧化。在丙二酸存在下，所有这些前体形成约等量的乙酰乙酸。酰基肉碱优先于丙酮酸被氧化，大概是因为脂肪酸β-氧化过程具有更强的竞争线粒体CoA的能力。柠檬酸循环抑制酮体(乙酰乙酸+β-羟基丁酸)的形成，部分通过抑制乙酰基的形成，部分通过将形成的乙酰基转移为柠檬酸形成。与肉碱结合脂肪酸形成酮体相比，丙酮酸形成酮体更容易被柠檬酸循环抑制。讨论了与在脂肪酸动员和利用增加的条件下发生的酮血症相关的结果。
The oxidation of L-caprinylcarnitine, L-palmitylcarnitine and pyruvate has been compared in rat-liver mitochondria. In the presence of malonate about equal amounts of acetoacetate are formed from all these precursors. The acylcarnitines are oxidized in preference to pyruvate, presumably because the fatty acid [beta] -oxidation process has a greater ability to compete for mito-chondrial CoA. The citric acid cycle suppresses the formation of ketone bodies (acetoacetate + [beta]-hydroxybutyrate), in part by suppressing the formation of acetyl groups, in part by diverting the acetyl groups formed to citrate formation. The ketone body formation from pyruvate is more easily suppressed by the citric acid cycle than is the formation of ketone bodies from the carnitine-bound fatty acids. The results are discussed in relation to the ketonemia which develops in conditions with increased fatty acid mobilization and utilization.