Highways of gene sharing in prokaryotes
Highways of gene sharing in prokaryotes
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DOI：
10.1073/pnas.0504068102
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发表时间：
2005-10-04
影响因子：
11.1
通讯作者：
Ragan, MA
中科院分区：
文献类型：
--
作者：
Beiko, RG;Harlow, TJ;Ragan, MA
横向遗传转移在多大程度上塑造了微生物基因组，对群落结构的出现有重大影响。我们对来自144种原核生物基因组的> 220，000种蛋白质进行了严格的系统发育分析，以确定基因共享对当前原核生物多样性的贡献，并确定谱系之间共享的“高速公路”。推断的关系表明，遗传模式，主要是垂直的，但有显着的例外，密切相关的类群之间，以及生活在类似环境中的远亲生物。
The extent to which lateral genetic transfer has shaped microbial genomes has major implications for the emergence of community structures. We have performed a rigorous phylogenetic analysis of > 220,000 proteins from genomes of 144 prokaryotes to determine the contribution of gene sharing to current prokaryotic diversity, and to identify "highways" of sharing between lineages. The inferred relationships suggest a pattern of inheritance that is largely vertical, but with notable exceptions among closely related taxa, and among distantly related organisms that live in similar environments.