Tetraspanins expressed in the embryonic chick nervous system.
Tetraspanins expressed in the embryonic chick nervous system.
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四跨膜蛋白在胚胎鸡神经系统中表达。
DOI：
10.1016/s0014-5793(99)01429-5
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发表时间：
1999
期刊：
影响因子：
3.5
通讯作者：
Bixby,JL
中科院分区：
文献类型：
--
作者：
Perron,JC;Bixby,JL
四跨膜蛋白超家族的蛋白质参与质膜信号复合物的形成;最近的证据表明神经元四跨膜蛋白参与轴突生长和靶点识别。我们使用简并PCR筛选来鉴定编码在胚胎脊髓中表达的四跨膜蛋白的cDNA。鉴定的两个cDNA显然代表NAG-2（cnag）和CD 9（chCD 9）的鸡同源物。第三个克隆编码一种新的四跨膜蛋白（neurospanin）。所有三种mRNA都广泛表达，但在神经系统中表现出发育上不同的表达模式。neurospanin和cag在包括脑、脊髓和背根神经节（DRG）在内的神经组织中表现出较高的相对表达。
Proteins of the tetraspanin superfamily participate in the formation of plasma membrane signaling complexes; recent evidence implicates neuronal tetraspanins in axon growth and target recognition. We used a degenerate PCR screen to identify cDNAs encoding tetraspanins expressed in the embryonic spinal cord. Two cDNAs identified apparently represent chick homologues of NAG-2 (cnag) and CD9 (chCD9). A third clone encodes a novel tetraspanin (neurospanin). All three mRNAs are widely expressed but exhibit developmentally distinct patterns of expression in the nervous system. Both neurospanin and cnag exhibit high relative expression in nervous tissue, including brain, spinal cord and dorsal root ganglia (DRG).