Pathological angiogenesis: mechanisms and therapeutic strategies.
Pathological angiogenesis: mechanisms and therapeutic strategies.
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DOI：
10.1007/s10456-023-09876-7
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发表时间：
2023-08
期刊：
影响因子：
9.8
通讯作者：
中科院分区：
文献类型：
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作者：
在多细胞生物体中，血管生成，即从先前存在的血管形成新血管，是生长和发育的重要过程。不同的机制，例如血管发生、发芽、套叠和联合血管生成，以及血管共选择、血管发生模仿和淋巴管生成，是新血管形成的基础。在许多病理条件下，如癌症、动脉粥样硬化、关节炎、牛皮癣、子宫内膜异位症、肥胖和SARS-CoV-2（COVID-19），发育性血管生成过程被重演，但通常在没有调节血管形成的普通空间和时间模式的正常反馈机制的情况下进行。因此，病理性血管生成为血管导向疗法的设计提出了新的挑战和新的机遇。在这里，我们概述了最近对血管发育的见解，并强调了促进或抑制血管生成过程以稳定，逆转甚至阻止疾病进展的新治疗策略。在我们的综述中，我们还将探讨与经典血管生成机制平行运作的几个其他方面（血管生成开关、缺氧、血管分泌信号、内皮可塑性、血管正常化和内皮细胞无反应性），并推测这些过程如何也可以通过抗血管生成或血管导向疗法来靶向。
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-existing ones, is an essential process for growth and development. Different mechanisms such as vasculogenesis, sprouting, intussusceptive, and coalescent angiogenesis, as well as vessel co-option, vasculogenic mimicry and lymphangiogenesis, underlie the formation of new vasculature. In many pathological conditions, such as cancer, atherosclerosis, arthritis, psoriasis, endometriosis, obesity and SARS-CoV-2(COVID-19), developmental angiogenic processes are recapitulated, but are often done so without the normal feedback mechanisms that regulate the ordinary spatial and temporal patterns of blood vessel formation. Thus, pathological angiogenesis presents new challenges yet new opportunities for the design of vascular-directed therapies. Here, we provide an overview of recent insights into blood vessel development and highlight novel therapeutic strategies that promote or inhibit the process of angiogenesis to stabilize, reverse, or even halt disease progression. In our review, we will also explore several additional aspects (the angiogenic switch, hypoxia, angiocrine signals, endothelial plasticity, vessel normalization, and endothelial cell anergy) that operate in parallel to canonical angiogenesis mechanisms and speculate how these processes may also be targeted with anti-angiogenic or vascular-directed therapies.
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影响因子：
9.8
作者：
Baganha F;de Jong RCM;Peters EA;Voorham W;Jukema JW;Delibegovic M;de Vries MR;Quax PHA
通讯作者：
Quax PHA
影响因子：
3.4
作者：
Betsholtz C
通讯作者：
Betsholtz C
影响因子：
9.8
作者：
通讯作者：
--
影响因子：
17.1
作者：
Allen E;Jabouille A;Rivera LB;Lodewijckx I;Missiaen R;Steri V;Feyen K;Tawney J;Hanahan D;Michael IP;Bergers G
通讯作者：
Bergers G
影响因子：
20.1
作者：
Bischoff J;Casanovas G;Wylie-Sears J;Kim DH;Bartko PE;Guerrero JL;Dal-Bianco JP;Beaudoin J;Garcia ML;Sullivan SM;Seybolt MM;Morris BA;Keegan J;Irvin WS;Aikawa E;Levine RA
通讯作者：
Levine RA