Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral-low grade diploid acinic cell carcinoma of the parotid gland
Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral-low grade diploid acinic cell carcinoma of the parotid gland
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DOI：
10.1007/s004280050353
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发表时间：
1999-04-01
期刊：
影响因子：
--
通讯作者：
Pilotti, S
中科院分区：
文献类型：
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作者：
Di Palma, S;Corletto, V;Pilotti, S
一个去分化腺泡细胞癌（AciCC）的右腮腺淋巴结转移发生在一个36岁的女性。该肿瘤与双侧分化良好的AciCC相关，该肿瘤的两个组分具有不同的（高和低）增殖活性（通过Mib-1测量）和不同的（非整倍体和二倍体）DNA含量。尽管存在高级别组分，但在p53位点未检测到TP 53突变、微卫星不稳定性（MSI）和/或杂合性丢失（洛）。虽然病人的随访时间很短，但肿瘤的侵袭性表现为4个月内右腮腺复发和区域转移的快速发展。
A dedifferentiated acinic cell carcinoma (AciCC) of the right parotid gland with lymph node metastases occurred in a 36-year-old woman. The tumour was associated with a bilateral well-differentiated AciCC, The two components of this tumour had different (high and low) proliferative activity measured by Mib-1 and different (aneuploid and diploid) DNA content. De spite the presence of a high-grade component, TP53 mutations, microsatellite instability (MSI) and/or loss of heterozygosity (LOH) at the p53 locus were not detected. Although the follow-up of the patient is very short, the aggressiveness of the tumour is shown by a recurrence in the right parotid within 4 months and by the rapid development of regional metastases.