Sodium metabisulphite induced airways disease in the fishing and fish-processing industry
Sodium metabisulphite induced airways disease in the fishing and fish-processing industry
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DOI：
10.1093/occmed/kqn130
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发表时间：
2008-12-01
影响因子：
5.1
通讯作者：
Ayres, J. G.
中科院分区：
文献类型：
--
作者：
Steiner, M.;Scaife, A.;Ayres, J. G.
背景偏亚硫酸钠（SMBS）被认为是一个潜在的原因气道刺激和可能的职业性哮喘，但其使用在渔业和鱼类加工industry.Aims和方法的认识是低的描述三例职业性气道疾病由于SMBS暴露和文献复习。1例因暴露于SMBS而患上了与工作有关的气道疾病，1例患有刺激物诱发的哮喘，并伴有与极高二氧化硫暴露相关的阳性特异性支气管激发，1例患有职业性哮喘，1例患有声带功能障碍和潜在哮喘。在文献中记录的9例病例中，大多数是非特应性的，对特定支气管激发的反应在进行时显示出立即反应。二氧化硫在这些环境中的暴露是非常高的，超过30 ppm。结论SMBS应被视为职业性呼吸道疾病的原因，其使用的鱼和虾加工业进一步调查，以更好地识别风险，从接触和处理的代理在工作场所。
Background Sodium metabisulphite (SMBS) is recognized as a potential cause of airway irritation and possibly occupational asthma, but awareness of its use in the fishing and fish-processing industry is low.Aims and methods To describe three cases of occupational airways disease due to SMBS exposure and to review the literature.Results Three patients, one trawlerman and two prawn processors, developed work-related airways disease due to exposure to SMBS, one with irritant-induced asthma with a positive-specific bronchial challenge associated with very high sulphur dioxide exposures, one with occupational asthma and one with vocal cord dysfunction and underlying asthma. Of the nine cases recorded in the literature, most were non-atopic and responses to specific bronchial challenge when undertaken showed an immediate response. Exposures to sulphur dioxide in these settings are very high, in excess of 30 ppm.Conclusion SMBS should be regarded as a cause of occupational airways disease and its use in the fish and prawn-processing industry investigated further to better identify risks from exposure and handling of the agent in the workplace.