Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves
Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves
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DOI：
10.1016/j.neuron.2008.03.013
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发表时间：
2008-05-22
期刊：
影响因子：
16.2
通讯作者：
Feller, Marla B.
中科院分区：
文献类型：
--
作者：
Elstrott, Justin;Anishchenko, Anastasia;Feller, Marla B.
视网膜的方向选择性需要将抑制输入不对称地连接到四种亚型的开-关方向选择性神经节细胞（DSGCs）上，每一种细胞都倾向于在四个基本方向中的一个方向上运动。方向选择性发展的主要模型是模式活动起指导作用。在这里，我们使用一种独特的、大规模的多电极阵列来证明，在黑暗中饲养的老鼠和缺乏胆碱能视网膜波的老鼠的眼睛睁开时，DSGCs存在。这些数据表明，视网膜的方向选择性在很大程度上独立于模式活动，因此可能是复杂分子相互作用的结果。
Direction selectivity in the retina requires the asymmetric wiring of inhibitory inputs onto four subtypes of On-Off direction-selective ganglion cells (DSGCs), each preferring motion in one of four cardinal directions. The primary model for the development of direction selectivity is that patterned activity plays an instructive role. Here, we use a unique, large-scale multielectrocle array to demonstrate that DSGCs are present at eye opening, in mice that have been reared in darkness and in mice that lack cholinergic retinal waves. These data suggest that direction selectivity in the retina is established largely independent of patterned activity and is therefore likely to emerge as a result of complex molecular interactions.