Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus
Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus
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DOI：
10.1152/jn.1998.80.6.3383
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发表时间：
1998-12-01
影响因子：
2.5
通讯作者：
Nicoll, RA
中科院分区：
文献类型：
--
作者：
Frerking, M;Malenka, RC;Nicoll, RA
据报道，脑源性神经营养因子（BDNF）对海马突触传递有快速影响。我们在这里报道，BDNF的大量应用导致CAI锥体细胞上刺激诱发的抑制性突触后电流（IPSCs）的少量但显著的减少，这是由酪氨酸激酶抑制剂lavendustin a阻止的。BDNF导致IPSC的1/CV2的减少，也减少了IPSC的配对脉冲抑制，提示突触前部位起作用。相比之下，BDNF对辐射层测量的场兴奋性突触后电位没有可检测到的影响。我们得出结论，BDNF对海马的抑制性传递具有选择性抑制作用，至少部分是由于突触前机制。
Brain-derived neurotrophic factor (BDNF) has been reported to have rapid effects on synaptic transmission in the hippocampus. We report here that bath application of BDNF causes a small but significant decrease in stimulus-evoked inhibitory postsynaptic currents (IPSCs) on CAI pyramidal cells, which is prevented by the tyrosine kinase inhibitor lavendustin A. BDNF causes a decrease in the 1/CV2 of the IPSC, and also reduces paired-pulse depression of the IPSC, suggesting a presynaptic site of action. In contrast, BDNF did not have a detectable effect on field excitatory postsynaptic potentials measured in stratum radiatum. We conclude that BDNF has a selective depressant action on inhibitory transmission in the hippocampus, due at least in part to a presynaptic mechanism.