Diploid growth pattern of hepatocellular tumours induced by various carcinogenic treatments.
Diploid growth pattern of hepatocellular tumours induced by various carcinogenic treatments.
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DOI：
10.1093/carcin/12.2.325
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发表时间：
1991-02
期刊：
影响因子：
4.7
通讯作者：
P. Schwarze;G. Sæter;D. Armstrong;R. Cameron;E. Laconi;D. Sarma;V. Préat;P. Seglen
中科院分区：
文献类型：
--
作者：
P. Schwarze;G. Sæter;D. Armstrong;R. Cameron;E. Laconi;D. Sarma;V. Préat;P. Seglen
来自不同品系大鼠的肝细胞癌，在不同实验室接受各种致癌治疗方案（由二乙基亚硝胺或二甲基肼引发，由苯巴比妥、2-乙酰氨基芴、萘芬诺平、乳清酸或脱氧胆酸促进，通过部分肝切除术或坏死性CCl 4处理的生长刺激），通过流式细胞术分析发现都主要是二倍体，与其中多倍体细胞核占优势的正常肝组织相反。因此，从多倍化到二倍体生长的转变似乎是恶性肝肿瘤的共同特性。良性肿瘤性肝结节同样以二倍体为主，但Fischer大鼠长期脱氧胆酸治疗诱导的结节除外。除了含有大多数多倍体细胞外，后者结节未能进展到癌阶段。
Hepatocellular carcinomas from rats of different strains, subjected to a variety of carcinogenic treatment regimens in different laboratories (initiation by diethylnitrosamine or dimethylhydrazine, promotion by phenobarbital, 2-acetylaminofluorene, nafenopin, orotic acid or deoxycholic acid, growth stimulation by partial hepatectomy or necrogenic CCl4 treatment), were all found to be predominantly diploid by flow cytometric analysis, in contrast to normal liver tissue in which polyploid nuclei were predominant. A switch from polyploidization to diploid growth would thus seem to be a common property of malignant liver tumours. Benign neoplastic liver nodules were likewise predominantly diploid, with the exception of nodules induced by long-term deoxycholic acid treatment in Fischer rats. In addition to containing a majority of polyploid cells, the latter nodules failed to progress to the carcinoma stage.