CONTROL OF NEURONAL DIVERSITY BY THE FLOOR PLATE - CONTACT-MEDIATED INDUCTION OF MIDBRAIN DOPAMINERGIC-NEURONS
CONTROL OF NEURONAL DIVERSITY BY THE FLOOR PLATE - CONTACT-MEDIATED INDUCTION OF MIDBRAIN DOPAMINERGIC-NEURONS
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DOI：
10.1016/0092-8674(95)90454-9
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发表时间：
1995-01-13
期刊：
影响因子：
64.5
通讯作者：
ROSENTHAL, A
中科院分区：
文献类型：
--
作者：
HYNES, M;POULSEN, K;ROSENTHAL, A
脊索和底板有助于形成腹侧神经管，部分是通过表达一种诱导运动神经元的扩散因子来实现的。为了确定指导其他类型腹侧神经元发育的机制，我们研究了位于腹侧中脑运动神经元附近的多巴胺能神经元的发育。我们提供的证据表明，多巴胺能神经元在底板附近发育，并且它们可以在体外和体内被底板所特异性。与运动神经元不同，多巴胺能神经元的有效诱导需要与底板细胞接触。这些结果表明，沿着背腹轴的神经元多样化可能部分是通过来自单一组织中心-底板的可扩散的和接触相关的信号的协同作用实现的。
The notochord and floor plate contribute to patterning the ventral neural tube in part by expressing a diffusible factor that induces motoneurons. To determine the mechanisms that direct the development of other classes of ventral neurons, we studied the development of dopaminergic neurons that reside near motoneurons in the ventral midbrain. We provide evidence that dopaminergic neurons develop in the vicinity of the floor plate and that they can be specified by the floor plate in vitro and in vivo. Unlike motoneurons, efficient induction of dopaminergic neurons requires contact with floor plate cells. These results suggest that neuronal diversification along the dorsal-ventral axis may be achieved partly through the concerted action of diffusible and contact-dependent signals from a single organizing center, the floor plate.