Resting-state brain entropy in schizophrenia
Resting-state brain entropy in schizophrenia
复制标题
精神分裂症静息态脑熵
DOI：
10.1016/j.comppsych.2018.11.015
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发表时间：
2019
影响因子：
7.3
通讯作者：
Wang Ze
中科院分区：
文献类型：
--
作者：
Xue Shao Wei;Yu Qingbao;Guo Yonghu;Song Donghui;Wang Ze
研究背景人脑呈现持续的时间波动，其动态范围反映了信息处理能力，可以用熵近似量化。利用功能磁共振成像（fMRI），最近的研究表明，一个稳定的分布模式的颞叶脑熵（tBEN）在健康受试者，这可能是受神经精神疾病，如精神分裂症。评估tBEN可能会提供一个新的工具来表征这些disorders.MethodsThe目前的研究旨在确定tBEN的变化，精神分裂症患者使用公开的数据从生物医学研究卓越中心（COBRE）项目。43例精神分裂症患者和59名性别和年龄相匹配的健康对照者，tBEN计算从他们的静息状态fMRI scans.ResultsCompared与健康对照组，患者表现出减少tBEN在右侧中前额叶皮质，双侧丘脑，右侧海马和双侧尾状核和增加tBEN在左侧舌回，左侧楔前叶，右侧梭状面区和右侧上级枕上回。精神分裂症患者左楔叶和枕中回tBEN与阳性症状和阴性症状评分（PANSS）呈负相关。发病年龄呈负相关，tBEN在右侧梭状回和左侧cross.ConclusionOur研究结果表明，精神分裂症的临床特征相关的有害tBEN减少。少数脑区tBEN的增加可能是精神分裂症患者tBEN在全脑重新分布的结果。
BackgroundThe human brain presents ongoing temporal fluctuations whose dynamic range indicates the capacity of information processing and can be approximately quantified with entropy. Using functional magnetic resonance imaging (fMRI), recent studies have shown a stable distribution pattern of temporal brain entropy (tBEN) in healthy subjects, which may be affected by neuropsychiatric diseases such as schizophrenia. Assessing tBEN may reciprocally provide a new tool to characterize those disorders.MethodsThe current study aimed to identify tBEN changes in schizophrenia patients using publicly available data from the Centers of Biomedical Research Excellence (COBRE) project. Forty-three schizophrenia patients and 59 sex- and age-matched healthy control subjects were included, and tBEN was calculated from their resting-state fMRI scans.ResultsCompared with healthy controls, patients showed decreased tBEN in the right middle prefrontal cortex, bilateral thalamus, right hippocampus and bilateral caudate and increased tBEN in the left lingual gyrus, left precuneus, right fusiform face area and right superior occipital gyrus. In schizophrenia patients, tBEN in the left cuneus and middle occipital gyrus was negatively correlated with the positive and negative syndrome scores (PANSS). Age of onset was inversely correlated with tBEN in the right fusiform gyrus and left insula.ConclusionOur findings demonstrate a detrimental tBEN reduction in schizophrenia that is related to clinical characteristics. The tBEN increase in a few regions might be a result of tBEN redistribution across the whole brain in schizophrenia.