Mapping neural activity patterns to contextualized fearful facial expressions onto callous-unemotional (CU) traits: intersubject representational similarity analysis reveals less variation among high-CU adolescents.
Mapping neural activity patterns to contextualized fearful facial expressions onto callous-unemotional (CU) traits: intersubject representational similarity analysis reveals less variation among high-CU adolescents.
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将神经活动模式映射到情境化的恐惧面部表情上，以示态感官（CU）特征：主体间表示相似性分析显示，高cu青少年的变化较少。
DOI：
10.1017/pen.2020.13
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发表时间：
2020
影响因子：
--
通讯作者：
Marsh AA
中科院分区：
文献类型：
--
作者：
Rhoads SA;Cardinale EM;O'Connell K;Palmer AL;VanMeter JW;Marsh AA
冷酷无情（CU）特质是早期出现的人格特征，其特征是同情心，对他人的关心和对社会违法行为的悔恨。与CU特征最相关的人际交往缺陷之一是对恐惧面部表情的行为和神经生理反应受损。然而，传统上在神经成像中采用的面部表情范例对于威胁的性质（即，感知者是威胁，还是环境中的其他东西？）。在本研究中，30名具有不同CU特征的青少年在接受功能性磁共振成像（fMRI）时观察了三种不同背景（“为你害怕”，“为你害怕”，“为自己害怕”）的恐惧面部表情。单变量分析发现，平均右杏仁核活动在“害怕自我”的背景下，与CU性状呈负相关。为了解开特殊刺激驱动的神经反应的目标，我们采用受试者间表征相似性分析将多体素神经反应模式中的受试者间相似性与具有CU特征的差异受试者间模型的情境化恐惧表达联系起来。在低CU青少年中，神经反应模式，而观看可怕的面孔是最一致的相似的早期视觉处理流和区域之间的情感反应，但更特质的情感面孔信息的皮质处理层次。相比之下，高CU青少年的神经反应模式始终沿着整个皮层层级排列（但在低CU青少年中出现分歧）。所观察到的模式不同的背景下，这表明，恐惧的表情的解释依赖于神经反应模式的程度，并进一步塑造了CU特征的水平。
Callous-unemotional (CU) traits are early-emerging personality features characterized by deficits in empathy, concern for others, and remorse following social transgressions. One of the interpersonal deficits most consistently associated with CU traits is impaired behavioral and neurophysiological responsiveness to fearful facial expressions. However, the facial expression paradigms traditionally employed in neuroimaging are often ambiguous with respect to the nature of threat (i.e., is the perceiver the threat, or is something else in the environment?). In the present study, 30 adolescents with varying CU traits viewed fearful facial expressions cued to three different contexts (“afraid for you,” “afraid of you,” “afraid for self”) while undergoing functional magnetic resonance imaging (fMRI). Univariate analyses found that mean right amygdala activity during the “afraid for self” context was negatively associated with CU traits. With the goal of disentangling idiosyncratic stimulus-driven neural responses, we employed intersubject representational similarity analysis to link intersubject similarities in multivoxel neural response patterns to contextualized fearful expressions with differential intersubject models of CU traits. Among low-CU adolescents, neural response patterns while viewing fearful faces were most consistently similar early in the visual processing stream and among regions implicated in affective responding, but were more idiosyncratic as emotional face information moved up the cortical processing hierarchy. By contrast, high-CU adolescents’ neural response patterns consistently aligned along the entire cortical hierarchy (but diverged among low-CU youths). Observed patterns varied across contexts, suggesting that interpretations of fearful expressions depend to an extent on neural response patterns and are further shaped by levels of CU traits.