Past and current status of adolescents living with HIV in South Africa, 2005-2017.
Past and current status of adolescents living with HIV in South Africa, 2005-2017.
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DOI：
10.1186/s13104-022-06006-2
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发表时间：
2022-04-09
影响因子：
1.8
通讯作者：
Nompumelelo Z
中科院分区：
文献类型：
--
作者：
Naidoo I;Takatshana S;Sewpaul R;Jooste S;Siyanai Z;Maseko G;Moyo S;Zuma K;Mabaso M;Nompumelelo Z
本文报告了艾滋病毒的流行率，发病率，实现联合国艾滋病规划署（90-90-90）的目标，艾滋病毒耐药性的青少年艾滋病毒感染者在南非的进展。我们使用从南非国家艾滋病毒流行率调查（2005-2017）中提取的数据进行了二次分析。按性别和年龄（10-14岁和15-19岁）对分析进行分层，提供加权描述性统计量和实际总数。艾滋病毒感染率从2012年的3.0%上升到2017年的3.7%，2017年有360，582名（95%CI 302，021-419，144）艾滋病毒阳性青少年。女性青少年的艾滋病毒感染率为5.6%，而男性为0.7%，这一比例不成比例。艾滋病毒感染率保持相对稳定。就艾滋病规划署的90-90-90目标而言，大约62.3%的青少年知道自己的艾滋病毒状况，其中65.4%的人正在接受抗逆转录病毒治疗，其中78.1%的人在接受抗逆转录病毒治疗后实现了病毒载量抑制。在南非，对围产期感染和产后感染的严重程度以及艾滋病毒在青少年中传播的社会行为风险因素存在知识差距。仍然需要针对青少年采取重点干预措施：（1）艾滋病毒风险的性别差异;（2）艾滋病毒筛查;（3）持续获得和坚持抗逆转录病毒治疗;（3）继续接受护理，以维持病毒载量抑制。
This paper reports HIV prevalence, incidence, progress towards the UNAIDS (90-90-90) targets, and HIV drug resistance among adolescents living with HIV in South Africa. We conducted secondary analyses using data extracted from the South African national HIV prevalence surveys (2005–2017). Analyses were stratified by sex and age (10–14 and 15–19-years), presenting weighted descriptive statistics, and realised totals. HIV prevalence increased from 3.0% in 2012 to 3.7% in 2017, translating to 360 582 (95% CI 302 021-419 144) HIV positive adolescents in 2017. Female adolescents bear a disproportionate HIV burden of 5.6% prevalence versus 0.7% for males. HIV incidence remained relatively stable. For the UNAIDS 90-90-90 targets, approximately 62.3% of adolescents knew their HIV status, 65.4% of whom were on antiretroviral therapy, and of these 78.1% on antiretroviral therapy had attained viral load suppression. There are knowledge gaps pertaining to the magnitude of perinatal infections and postnatal infections, and socio-behavioural risk factors for HIV transmission among adolescents in South Africa. There is still a need for focussed interventions targeting adolescent (1) gender disparities in HIV risk (2) screening for HIV, (3) sustained access and adherence to antiretroviral therapy and (3) retention in care to maintain viral load suppression.