Cloning and expression patterns of dystroglycan during the early development of Xenopus laevis.
Cloning and expression patterns of dystroglycan during the early development of Xenopus laevis.
复制标题
非洲爪蟾早期发育过程中肌营养不良聚糖的克隆和表达模式。
DOI：
10.1007/s00427-003-0328-6
复制
发表时间：
2003
影响因子：
2.4
通讯作者：
Darribère,Thierry
中科院分区：
文献类型：
--
作者：
Moreau,Nicole;Alfandari,Dominique;Gaultier,Alban;Cousin,Hélène;Darribère,Thierry
Dystroglycan is a cell surface receptor involved in the pathogenesis of muscular dystrophy, and plays a critical role in the assembly and homeostasis of basement membranes. Since data about the amphibian homologue are limited, we have cloned the full-length dystroglycan cDNAs from the frogXenopus laevis. Using in situ hybridization, we show that mRNA expression is dynamic, particularly in the notochord at the end of gastrulation and during neurulation, suggesting that the protein might play unexplored roles in the specification and/or formation of this tissue. Subsequently, the transcripts are detected in the otic vesicle, the developing brain, and in mesenchymal cells of the visceral arches, as well as in pharyngeal endoderm, the pronephros, pronephric ducts, proctodaeum and the somites.
