Localized irregularities in hemoglobin flow and oxygenation in calf muscle in patients with peripheral vascular disease detected with near-infrared spectrophotometry
Localized irregularities in hemoglobin flow and oxygenation in calf muscle in patients with peripheral vascular disease detected with near-infrared spectrophotometry
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DOI：
10.1067/mva.2003.214
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发表时间：
2003-05-01
影响因子：
4.3
通讯作者：
Gratton, E
中科院分区：
文献类型：
--
作者：
Wolf, U;Wolf, M;Gratton, E
目的：近红外分光光度法用于测量组织中几厘米深的小动脉、毛细血管和小静脉中血红蛋白的流量、浓度和氧合。本研究的目的是调查有记录的外周动脉闭塞性疾病（PVD）患者、有PVD危险因素的患者和健康的年轻受试者在休息时小腿肌肉中血红蛋白的流量、浓度和氧合的分布。利用频域近红外分光光度计和专门设计的探头，我们在22个位置同时生成了血红蛋白流量、浓度和氧合，用静脉闭塞法。对7例PVD患者（PVD组）、8例踝臂指数正常但有PVD危险因素的患者（RF组）和8例健康人（H组）的16条患肢进行了研究。结果：PVD组8条患肢的踝臂指数均高于H组（P < 0.05）。
Purpose: Near-infrared spectrophotometry is used to measure flow, concentration, and oxygenation of hemoglobin in arterioles, capillaries, and venules several centimeters deep in tissue. The purpose of this study was to investigate the distribution of flow, concentration, and oxygenation of hemoglobin in calf muscle in patients with documented peripheral arterial occlusive disease (PVD), patients with risk factors for PVD and healthy younger subjects at rest.Method: With a frequency-domain near-infrared spectrophotometer and a specially designed probe, we generated maps at 22 locations simultaneously of hemoglobin flow, concentration, and oxygenation, with the venous occlusion method. Eight legs of 7 patients with diagnosed PVD (PVD group), 10 legs of 8 patients with normal ankle-brachial index but with risk factors for PVD (RF group), and 16 legs of 8 healthy subjects (H group) were studied.Results: Global mean values were significantly (P