Ambient particle radioactivity and gestational diabetes: A cohort study of more than 1 million pregnant women in Massachusetts, USA.
Ambient particle radioactivity and gestational diabetes: A cohort study of more than 1 million pregnant women in Massachusetts, USA.
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DOI：
10.1016/j.scitotenv.2020.139340
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发表时间：
2020-05
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通讯作者：
S. Papatheodorou;D. Gold;Annelise J. Blomberg;M. Hacker;B. Wylie;W. Réquia;E. Oken;A. Fleisch;J. Schwartz;P. Koutrakis
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作者：
S. Papatheodorou;D. Gold;Annelise J. Blomberg;M. Hacker;B. Wylie;W. Réquia;E. Oken;A. Fleisch;J. Schwartz;P. Koutrakis
背景电离辐射暴露会增加慢性代谢紊乱如胰岛素抵抗和2型糖尿病的风险。吸入放射性气溶胶的内部电离辐射可能有助于细颗粒物（PM2.5）和妊娠期糖尿病（GDM）之间的关联。MethodsWe使用马萨诸塞州生命记录登记处研究了2001年至2015年1，061，937名无糖尿病单胎妊娠的孕妇。美国环境保护局RadNet监测网络的7个监测器测量的总β放射性被用来代表环境粒子放射性（PR）。我们从出生证明中获得GDM状态，并使用logistic回归分析调整社会人口统计学，母亲合并症，PM2.5，温度和相对湿度。我们还研究了吸烟habites.ResultsAmbient粒子放射性暴露在怀孕的第一和第二个三个月与GDM（OR：1.18（95%CI 1.10至1.22）的几率较高。控制PM2.5并不能显著改变PR对GDM的影响。在报告为前吸烟者或当前吸烟者的女性中，PR和GDM之间的关联为零。在整个队列中，PM2.5对GDM的整体效果没有调整PR是不显着的。ConclusionThis是第一个以人口为基础的研究，检查粒子放射性和妊娠期糖尿病之间的关联-最常见的妊娠相关疾病之一，终身影响的母亲和胎儿。这一发现具有重要的公共卫生政策意义，因为它增强了我们对PR毒性的理解，PR是一种可改变的风险因素，迄今为止，它仅被认为是室内和职业空气质量风险。
BackgroundExposure to ionizing radiation increases the risk of chronic metabolic disorders such as insulin resistance and type 2 diabetes. Internal ionizing radiation from inhaled radioactive aerosol may contribute to the associations between fine particulate matter (PM2.5) and gestational diabetes mellitus (GDM).MethodsWe used the Massachusetts Registry of Vital Records to study 1,061,937 pregnant women from 2001 to 2015 with a singleton pregnancy without pre-existing diabetes. Gross β activity measured by seven monitors of the U.S. Environmental Protection Agency's RadNet monitoring network was utilized to represent ambient particle radioactivity (PR). We obtained GDM status from birth certificates and used logistic regression analyses adjusted for socio-demographics, maternal comorbidities, PM2.5, temperature and relative humidity. We also examined effect modification by smoking habits.ResultsAmbient particle radioactivity exposure during first and second trimester of pregnancy was associated with higher odds of GDM (OR: 1.18 (95% CI 1.10 to 1.22). Controlling for PM2.5did not substantially change the effects of PR on GDM. In women that reported being former or current smokers, the association between PR and GDM was null. In the full cohort, the overall effect of PM2.5on GDM without adjusting for PR was not significant.ConclusionThis is the first population-based study to examine the association between particle radioactivity and gestational diabetes mellitus - one of the most common pregnancy-related diseases with lifelong effects for the mother and the fetus. This finding has important public health policy implications because it enhances our understanding about the toxicity of PR, a modifiable risk factor, which to date, has been considered only as an indoor and occupational air quality risk.