Distribution of Metastatic Cancer Cells in Colorectal Mesentery
Distribution of Metastatic Cancer Cells in Colorectal Mesentery
复制标题
结直肠系膜转移癌细胞的分布
DOI：
10.1007/s00268-019-05284-5
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发表时间：
2020-03-01
影响因子：
2.6
通讯作者：
Gong, Jian-Ping
中科院分区：
文献类型：
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作者：
Ma, Chen-Sen;Tong, Yi-Xin;Gong, Jian-Ping
背景：目的探讨肠系膜转移癌细胞（简称转移V）的分布情况，丰富对结直肠癌转移的认识。方法纳入2018年4月至2018年12月在华中科技大学同济医学院附属同济医院消化外科接受结直肠手术的患者299例。术后从解剖的肠系膜中获取样本，并使用苏木精-伊红染色或免疫组织化学检测转移性癌细胞。记录病理因素，包括肿瘤位置、肿瘤大小、浸润深度、肿瘤分化、淋巴结受累、局部血管侵犯和神经周围侵犯。结果299例患者中，62例检测到结直肠系膜转移癌细胞（转移V）。转移V与肿瘤浸润深度、淋巴结转移、肿瘤分化以及癌细胞的神经周围和血管侵袭密切相关。 T3 期 (26.27%) 和 T4 期 (40.00%) 患者的 V 转移发生率高于 T1 和 T2 期患者（分别为 0% 和 2%）。在 N2a 和 N2b 期肿瘤患者中经常检测到转移 V（分别为 51.72% 和 61.54%）。转移 V 在神经周围转移和局部血管侵犯的患者中更常见。此外，结肠癌和直肠癌V转移的发生率相似。结论V转移的发生率与肿瘤分期因素相关，且多发生于晚期患者。
BackgroundTo investigate the distribution of metastatic cancer cells in the mesentery (referred to as metastasis V) and enrich the understanding of the metastasis of colorectal cancer.MethodsA total of two hundred ninety‐nine patients who received colorectal operations at the Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology between April 2018 and December 2018 were included. Samples were acquired from the dissected mesentery after the operation, and hematoxylin–eosin staining or immunohistochemistry was used to detect metastatic cancer cells. Pathological factors, including tumor position, tumor size, invasion depth, tumor differentiation, lymph node involvement, local vessel invasion, and perineural invasion, were recorded.ResultsMetastatic cancer cells in the colorectal mesentery (metastasis V) were detected in 62 of 299 patients. Metastasis V was closely correlated with tumor invasion depth, lymph node metastasis, tumor differentiation, and perineural and vessel invasion by cancer cells. Metastasis V occurred more frequently in patients with T3 stage (26.27%) and T4 stage (40.00%) than in patients with T1 and T2 stages (0% and 2%, respectively). Metastasis V was frequently detected in patients with N2a and N2b stage tumors (51.72% and 61.54%, respectively). Metastasis V was more frequently detected in patients with perineural metastasis and local vessel invasion. In addition, metastasis V incidences in colon and rectal cancer were similar.ConclusionThe incidence rate of metastasis V is correlated with tumor staging factors and occurs more frequently in advanced‐stage patients.