FURTHER STUDIES ON THE REACTION BETWEEN HALOGEN-SUBSTITUTED NITRILES AND AMINES
FURTHER STUDIES ON THE REACTION BETWEEN HALOGEN-SUBSTITUTED NITRILES AND AMINES
复制标题
卤素取代腈与胺反应的进一步研究
DOI：
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发表时间：
1961
期刊：
影响因子：
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通讯作者：
A. Taurins
中科院分区：
文献类型：
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作者：
J. C. Grivas;A. Taurins
通过包括三氟乙腈和二氯乙腈，扩大了卤素取代的腈和胺的反应范围。三氟乙腈很容易与伯胺和仲胺、伯胺、芳胺和杂环胺反应生成相应的胺。以二氯乙腈和胺为原料合成了N-一取代和N-二取代二氯乙酰胺，三氯乙腈还提供了带有杂环胺的N-取代二氯乙酰胺。
The scope of the reaction of halogen-substituted nitriles and amines was extended by including trifluoro- and dichloro-acetonitrile. Trifluoroacetonitrile reacts easily with primary and secondary aliphatic, primary aromatic, and heterocyclic amines to give the corresponding amidines. N-Mono- and N-di-substituted dichloroacetamidines were prepared from dichloro-acetonitrile and amines, Trichloroacetonitrile also affords N-substituted amidines with heterocyclic amines.