Agent-Based Modeling in Systems Pharmacology.
Agent-Based Modeling in Systems Pharmacology.
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DOI：
10.1002/psp4.12018
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Coles M
中科院分区：
文献类型：
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作者：
Cosgrove J;Butler J;Alden K;Read M;Kumar V;Cucurull-Sanchez L;Timmis J;Coles M
建模和模拟 (M&S) 技术为知识整合和假设检验提供了一个平台，以深入了解先验不可能的生物系统。基于主体的建模 (ABM) 是一种 M&S 技术，专注于描述单个组件而不是同质群体。本教程向系统药理学家介绍 ABM，使用相关案例研究来强调 ABM 的特定优势如何在临床前机制建模领域取得成功。
Modeling and simulation (M&S) techniques provide a platform for knowledge integration and hypothesis testing to gain insights into biological systems that would not be possible a priori. Agent‐based modeling (ABM) is an M&S technique that focuses on describing individual components rather than homogenous populations. This tutorial introduces ABM to systems pharmacologists, using relevant case studies to highlight how ABM‐specific strengths have yielded success in the area of preclinical mechanistic modeling.