Targeting the Metastatic Bone Microenvironment by MicroRNAs.
Targeting the Metastatic Bone Microenvironment by MicroRNAs.
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DOI：
10.3389/fendo.2018.00202
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发表时间：
2018
影响因子：
5.2
通讯作者：
Taipaleenmäki H
中科院分区：
文献类型：
--
作者：
Haider MT;Taipaleenmäki H
骨转移是晚期乳腺癌的常见且具有破坏性的特征。转移性骨疾病是由于癌细胞与骨微环境 (BME) 之间的病理相互作用导致骨重塑紊乱的结果。在 BME 中，乳腺癌细胞严重改变了由成骨细胞和破骨细胞驱动的骨形成和骨吸收的平衡。 BME 中复杂的细胞串扰由分泌分子、信号通路和表观遗传线索（包括非编码 RNA）控制。 MicroRNA (miRNA) 是一种小型非编码 RNA，可降低蛋白质丰度并调节多种生物过程，包括骨重塑。在病理条件下，异常的 miRNA 信号传导会导致骨转移等疾病的进展。最近，miRNA 已被证明可以调节骨转移的几个关键驱动因素。此外，miRNA 是转移性 BME 内细胞相互作用的重要调节因子。因此，据报道，通过 miRNA 递送或拮抗作用来靶向 BME 可以限制实验和临床前条件下的疾病进展，从而将 miRNA 定位为转移性骨病的新兴新型治疗工具。本综述将总结我们目前对转移性 BME 的组成和功能的理解，并讨论 miRNA 如何调节骨环境中病理相互作用的最新进展。
Bone metastases are a common and devastating feature of late-stage breast cancer. Metastatic bone disease is a consequence of disturbed bone remodeling due to pathological interactions between cancer cells and the bone microenvironment (BME). In the BME, breast cancer cells severely alter the balanced bone formation and bone resorption driven by osteoblasts and osteoclasts. The complex cellular cross talk in the BME is governed by secreted molecules, signaling pathways and epigenetic cues including non-coding RNAs. MicroRNAs (miRNAs) are small non-coding RNAs that reduce protein abundance and regulate several biological processes, including bone remodeling. Under pathological conditions, abnormal miRNA signaling contributes to the progression of diseases, such as bone metastasis. Recently miRNAs have been demonstrated to regulate several key drivers of bone metastasis. Furthermore, miRNAs are implicated as important regulators of cellular interactions within the metastatic BME. As a consequence, targeting the BME by miRNA delivery or antagonism has been reported to limit disease progression in experimental and preclinical conditions positioning miRNAs as emerging novel therapeutic tools in metastatic bone disease. This review will summarize our current understanding on the composition and function of the metastatic BME and discuss the recent advances how miRNAs can modulate pathological interactions in the bone environment.
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影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D
影响因子：
4
作者：
Johnson RW;Merkel AR;Page JM;Ruppender NS;Guelcher SA;Sterling JA
通讯作者：
Sterling JA
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
4.1
作者：
Hackl, Matthias;Heilmeier, Ursula;Grillari, Johannes
通讯作者：
Grillari, Johannes
影响因子：
4
作者：
Brown, H. K.;Ottewell, P. D.;Holen, I.
通讯作者：
Holen, I.