Knowledge, attitudes, and perceptions about antibiotic use and antimicrobial resistance among final year undergraduate medical and pharmacy students at three universities in East Africa.
Knowledge, attitudes, and perceptions about antibiotic use and antimicrobial resistance among final year undergraduate medical and pharmacy students at three universities in East Africa.
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DOI：
10.1371/journal.pone.0251301
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Mushi MF
中科院分区：
文献类型：
--
作者：
Lubwama M;Onyuka J;Ayazika KT;Ssetaba LJ;Siboko J;Daniel O;Mushi MF
考虑到预计到2050年抗菌素耐药性的负担将增加，采取适当措施打击撒哈拉以南非洲抗菌素耐药性的发展和传播至关重要。对医生和药学专业学生进行抗菌药物管理方面的培训对于对抗抗菌药物耐药性至关重要。本研究旨在评估乌干达，肯尼亚和坦桑尼亚三所大学的最后一年医学和药学学生对抗菌药物使用和抗菌药物耐药性的知识，态度和看法。在东非三所大学的最后一年本科医学和药学学生中进行了横断面调查。开发了自填式问卷，其中包括二分问题和使用4点Likert量表的问题。这些问题是基于对抗生素的知识和态度，以及在临床情况下使用抗生素的准备。根据研究目的，使用STATA第16版分析数据。来自MUK 75，MKU 75和CUHAS 178的328名最后一年的学生参加了调查。大多数参与者为男性192（58.5%），他们的中位年龄为25 [23 - 27]岁。总体而言，36.6%（120/328）的学生总体知识水平良好。与MKU和CUHAS相比，MUK的学生更多地拥有良好的知识（72%对40%对20.2%; p <0.001）。总体良好的总知识、抗生素一般知识、抗生素耐药性知识和临床使用抗生素知识的平均得分分别为58%（CI：57%-60%）、95%（CI：94%-97%）、54%（CI：52%-56%）和46%（CI：44%-48%）。与医学生相比，更多的药学生对抗生素使用有良好的态度和看法（79.6%对68.4%; p = 0.026）。CUHAS的学生认为与MKU和MUK相比，他们更愿意在地区医院使用抗生素（75.3%对62.7%对65.3%; p = 0.079）。虽然二百七十82.3%的学生认为知道何时开始抗菌药物治疗，112（34.2%）不知道如何选择合适的抗生素（p <0.0001），97（29.6%）不知道抗生素给药剂量111例（33.8%）不知道何时从静脉抗生素转为口服抗生素（p <0.0001）。最后一年的学生在抗菌药物耐药性和临床应用抗生素方面的知识得分较低。这暴露了学生在实际培训方面的差距，虽然他们可能感到自信，但还没有完全准备好在医院开抗生素。应采取涉及东非地区医学院的多学科和实用方法，对最后一年的本科生进行抗菌药物耐药性和抗菌药物管理项目的培训。抗菌素耐药性和抗菌素管理课程应引入到最后一年的医学和药学课程。
Proper measures to combat antimicrobial resistance development and spread in Sub Saharan Africa are very crucial bearing in mind the projected burden of antimicrobial resistance which is expected to be increase by 2050. Training of medical doctor and pharmacy students in antimicrobial stewardship is vital to combat antimicrobial resistance. This study was designed to evaluate the knowledge, attitude, and perception of final year medical and pharmacy students on antimicrobial use and antimicrobial resistance at three universities in Uganda, Kenya, and Tanzania. A cross-sectional survey was carried out among final year undergraduate medical and pharmacy students at three universities in East Africa. A Self-administered questionnaire was developed which included dichotomous questions and questions using a 4-point Likert scale. The questions were based on knowledge and attitude about antibiotics, and preparedness to use antibiotics in clinical scenarios. Data were analyzed using STATA version 16 following the objective of the study. Three hundred and twenty-eight final year students participated in the survey from MUK 75, MKU 75 and CUHAS 178. Slightly majority of participants were male 192(58.5%) and their median age was 25 [23 – 27] years. In general, 36.6% (120/328) of students had good overall total knowledge. More students at MUK had good knowledge compared to MKU, and CUHAS (72% vs, 40% vs. 20.2%; p<0.001). The mean scores for overall good total knowledge, general knowledge about antibiotics, knowledge about antibiotic resistance, and knowledge about antibiotic use in clinical scenarios were 58% (CI: 57%– 60%), 95% (CI: 94%– 97%), 54% (CI: 52% - 56%), and 46% (CI:44% - 48%) respectively. More pharmacy students compared to medical students had a good attitude and perception on antibiotic use (79.6% vs. 68.4%; p = 0.026). The students at CUHAS perceived being more prepared to use antibiotic in district hospitals compared to MKU and MUK (75.3% vs. 62.7% vs. 65.3%; p = 0.079). While two hundred and seventy (82.3%) students perceived knowing when to start antimicrobial therapy, 112 (34.2%) did not know how to select the appropriate antibiotic (p<0.0001), 97 (29.6%) did not know the antibiotic dose to give (p<0.0001), and 111 (33.8%) did not know when to switch form an intravenous antibiotic to oral regimen (p<0.0001). Final year students have low scores in knowledge about antimicrobial resistance and antibiotic use in clinical scenarios. This has exposed gaps in practical training of students, while they may feel confident, are not fully prepared to prescribe antibiotics in a hospital setting. A multidisciplinary and practical approach involving medical schools across the East African region should be undertaken to train final year undergraduate students in antimicrobial resistance and antimicrobial stewardship programs. Antimicrobial resistance and antimicrobial stewardship courses should be introduced into the curriculum of final year medicine and pharmacy programs.
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影响因子：
3.4
作者：
Keijsers, Carolina J. P. W.;Brouwers, Jacobus R. B. J.;Jansen, Paul A. F.
通讯作者：
Jansen, Paul A. F.
DOI：
10.3390/antibiotics9110821
发表时间：
2020-11-17
期刊：
Antibiotics (Basel, Switzerland)
影响因子：
--
作者：
Efthymiou P;Gkentzi D;Dimitriou G
通讯作者：
Dimitriou G
DOI：
10.1080/23120053.2016.1192808
发表时间：
2016-01-01
影响因子：
0.9
作者：
Burger, Marisa;Fourie, Jaco;Meyer, Johanna C.
通讯作者：
Meyer, Johanna C.
影响因子：
15.8
作者：
Sulis, Giorgia;Adam, Pierrick;Pai, Madhukar
通讯作者：
Pai, Madhukar
影响因子：
4.6
作者：
Di Gennaro, F.;Marotta, C.;Fantoni, M.
通讯作者：
Fantoni, M.