Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets through the secretion of TGF-β
Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets through the secretion of TGF-β
复制标题
骨髓基质细胞的管理通过 TGF-β 的分泌改变 Th1/Th2/Th17/Treg 细胞亚群的平衡来改善实验性自身免疫性重症肌无力
DOI：
10.1016/j.jneuroim.2008.12.005
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发表时间：
2009-02-15
影响因子：
3.3
通讯作者：
Li, Hu-lun
中科院分区：
文献类型：
--
作者：
Kong, Qing-fei;Sun, Bo;Li, Hu-lun
骨髓基质细胞（BMSC）是细胞治疗人类自身免疫性疾病的有力候选细胞。静脉注射同系BMSCs对EAMG模型大鼠有效地改善了疾病，部分是通过TGF-β依赖性机制。BMSCs与EAMG大鼠T、B细胞在适当比例下共培养，可抑制EAMG大鼠T、B细胞的增殖。BMSCs可纠正EAMG发生发展过程中Th 1、Th 2、Th 17和Treg细胞亚群的失衡。这些结果为MG，EAMG和其他免疫介导的疾病的发病机制提供了进一步的见解，并支持BMSCs在其治疗中的潜在作用。(C)2008 Elsevier B. V.保留所有权利。
Bone marrow stromal cells (BMSCs) are strong candidates for cell therapy against human autoimmune diseases. Intravenous administration of syngenic BMSCs to EAMG-model rats effectively ameliorated the disease, partially through a TGF-beta-dependent mechanism. The proliferative ability of T or B cells from EAMG rats was inhibited by BMSCs at proper cocultured ratios. And the imbalance of Th1, Th2, Th17 and Treg cell subsets accompanied with the development of EAMG was corrected by the administration of BMSCs. These results provide further insights into the pathogenesis of MG, EAMG, and other immune-mediated diseases, and support a potential role for BMSCs in their treatment. (C) 2008 Elsevier B.V. All rights reserved.