Association of SNP rs1447295 and Microsatellite Marker DG8S737 With Familial Prostate Cancer and High Grade Disease
Association of SNP rs1447295 and Microsatellite Marker DG8S737 With Familial Prostate Cancer and High Grade Disease
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DOI：
10.1016/j.juro.2010.03.102
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发表时间：
2010-08-01
影响因子：
6.6
通讯作者：
Suzuki, Kazuhiro
中科院分区：
文献类型：
--
作者：
Hamano, Tatsuya;Matsui, Hiroshi;Suzuki, Kazuhiro
目的：一些先前的研究表明染色体8 q24的遗传标记与前列腺癌风险增加之间的关系。我们证实了8 q24标志物与前列腺癌在日本人口和这些遗传变异与临床characteristics.Materials和方法：包括在这项研究中的134例家族性前列腺癌，158散发性前列腺癌和119对照组的关联。都是日本人。我们使用荧光标记引物进行实时聚合酶链反应和基于聚合酶链反应的检测，对2，8 q24标记SNP rs 1447295和微卫星标记DG 8 S737进行基因分型。DG 85737 - 12等位基因与家族性前列腺癌风险显著正相关（OR 1.86，95%CI 1.11-3.00，p = 0.02），风险与rs 1447295 A等位基因显著相关（OR 2.36，95%CI 1.41-3.94，p = 0.002）。显着协会指出，每个标志物在男性与高Gleason score.Conclusions：两个等位基因在8 q24的遗传危险因素家族性前列腺癌和高级别的疾病。
Purpose: Several prior studies show a relationship between genetic markers at chromosome 8q24 and an increased prostate cancer risk. We confirmed the association of 8q24 markers with prostate cancer in the Japanese population and the association of these genetic variants with clinical characteristics.Materials and Methods: Included in this study were 134 patients with familial prostate cancer, 158 with sporadic prostate cancer and 119 controls. All were Japanese. We genotyped the 2, 8q24 markers SNP rs1447295 and microsatellite marker DG8S737 using real-time polymerase chain reaction and polymerase chain reaction based assay with fluorescence labeled primers.Results: There was a significant positive association between the DG85737 - 12 allele and familial prostate cancer risk (OR 1.86, 95% CI 1.11-3.00, p = 0.02) and a significant association of risk with the rs1447295 A allele (OR 2.36, 95% CI 1.41-3.94, p = 0.002). Significant associations were noted for each marker in men with a high Gleason score.Conclusions: Two alleles at 8q24 are genetic risk factors for familial prostate cancer and high grade disease.