Bisphenol A affects endocrine physiology and biotransformation enzyme activities of the field vole (Microtus agrestis).
Bisphenol A affects endocrine physiology and biotransformation enzyme activities of the field vole (Microtus agrestis).
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DOI：
10.1006/gcen.2002.7792
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发表时间：
2002-04
影响因子：
2.7
通讯作者：
P. Nieminen;P. Lindström-Seppä;A. Mustonen;H. Mussalo-Rauhamaa;J. Kukkonen
中科院分区：
文献类型：
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作者：
P. Nieminen;P. Lindström-Seppä;A. Mustonen;H. Mussalo-Rauhamaa;J. Kukkonen
双酚A（BPA）是一种环境雌激素，以三种剂量（10、50或250 mg/kg/d）皮下注射给48只田鼠，持续4天。测定血浆性类固醇、甲状腺素、体重调节激素和肝生物转化酶。对照组中没有死亡，但BPA暴露动物的死亡率很高。BPA在250 mg BPA/kg（-1）天（-1）时增加血浆睾酮浓度。在50或250 mg BPA/kg（-1）天（-1）时，从合并血浆中测得的血浆ghrelin水平升高，同时从合并血浆中测得的瘦素水平降低。在所有剂量下，肝脏7-乙氧芸香苷-O-脱乙基酶活性略有下降，在250 mg BPA/kg/天剂量下，肝脏细胞溶质谷胱甘肽S-转移酶活性也略有下降。结果表明，野生哺乳动物，如田鼠可能比实验室啮齿动物更容易受到BPA的影响。需要对野生哺乳动物进行更多的研究，以确定内分泌干扰物在自然生态系统中的风险。
Bisphenol A (BPA), an environmental estrogen, was given subcutaneously for 4 days to 48 field voles at three doses (10, 50, or 250 mg kg(-1) day(-1)). Plasma sex steroids, thyroxine, weight-regulatory hormones, and liver biotransformation enzymes were determined. There was no mortality in the control group but the mortality in the BPA-exposed animals was significant. BPA increased the plasma testosterone concentrations at 250 mg BPA kg(-1) day(-1). The plasma ghrelin levels measured from pooled plasma increased and at the same time the leptin levels measured from pooled plasma decreased at 50 or 250 mg BPA kg(-1) day(-1). The liver 7-ethoxyrufin-o-deethylase activity decreased slightly at all doses, as did the liver cytosolic glutathione S-transferase activity at 250 mg BPA kg(-1) day(-1). The results show that wild mammals such as the field vole could be more susceptible to BPA than laboratory rodents. More studies on wild mammals are needed to determine the risks of endocrine disruptors in natural ecosystems.