Functional connectivity in the thalamus and hippocampus studied with functional MR imaging.
Functional connectivity in the thalamus and hippocampus studied with functional MR imaging.
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发表时间：
2000-09
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通讯作者：
T. Stein;C. Moritz;Michelle Quigley;D. Cordes;V. Haughton;Elizabeth Meyerand
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作者：
T. Stein;C. Moritz;Michelle Quigley;D. Cordes;V. Haughton;Elizabeth Meyerand
背景与目的通过功能连接的功能性磁共振成像，在没有执行认知任务的参与者中，信号强度的协方差显示在大脑功能相关区域。这些变化被认为代表了血流的同步波动，这意味着这些区域之间的神经元连接。本研究的目的是通过功能连接功能磁共振成像来绘制皮质下核的功能连接。方法对6名未执行特定认知任务的志愿者进行回波平面序列成像。对于功能连接功能磁共振成像，从丘脑或海马体的静息数据集中选择一个或一组“种子”体素。灰质中的控制体素也被认为不是雄辩皮层。计算种子体素和控制体素与静息数据集中其他体素的相关系数。将相关系数大于或等于0.5的体素映射到解剖图像上，用于功能连接功能MR图像。这些体素的解剖位置由传统的分割方法确定。结果：对于每个参与者，基于丘脑或海马中的四个种子体素的功能连接功能磁共振成像图显示同侧和对侧丘脑或海马中的体素簇。在对照体素中，海马和丘脑中很少有体素表现出显著的相关性。与对侧海马相比，同侧海马中与种子体素相关的像素明显更多。同侧丘脑与对侧丘脑功能连接体素数差异不显著。结论：丘脑和海马体显示功能连通性，可能代表了血流的同步变化。
BACKGROUND AND PURPOSE With functional connectivity functional MR imaging, co-variance in signal intensity has been shown in functionally related regions of brain in participants instructed to perform no cognitive task. These changes are thought to represent synchronous fluctuations in blood flow, which imply neuronal connections between the regions. The purpose of this study was to map functional connectivity in subcortical nuclei with functional connectivity functional MR imaging. METHODS Imaging data were acquired with an echo-planar sequence from six volunteers who performed no specific cognitive task. For functional connectivity functional MR imaging, a "seed" voxel or group of voxels was selected from the resting data set in the thalamus or in the hippocampus. Control voxels in gray matter presumed not to be eloquent cortex were also chosen. The correlation coefficient of the seed voxels and the control voxels with every other voxel in the resting data set was calculated. The voxels with correlation coefficients greater than or equal to 0.5 were mapped onto anatomic images for the functional connectivity functional MR images. The anatomic location of these voxels was determined by conventional parcellation methods. RESULTS For each participant, functional connectivity functional MR imaging maps based on four seed voxels in the thalamus or hippocampus showed clusters of voxels in the ipsilateral and contralateral thalamus or hippocampus. For control voxels, few voxels in the hippocampus or thalamus showed significant correlation. Significantly more pixels in the ipsilateral hippocampus correlated with the seed voxel than in the contralateral hippocampus. The differences between numbers of functionally connected voxels in ipsilateral thalamus and those in contralateral thalamus were not significant. CONCLUSIONS The thalamus and hippocampus show functional connectivity, presumably representing synchronous changes in blood flow.