When Doors of Perception Open: Visual Contrast Sensitivity in Never-Medicated, First-Episode Schizophrenia
When Doors of Perception Open: Visual Contrast Sensitivity in Never-Medicated, First-Episode Schizophrenia
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DOI：
10.1037/a0019610
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发表时间：
2010-08-01
影响因子：
4.6
通讯作者：
Keri, Szabolcs
中科院分区：
文献类型：
--
作者：
Kiss, Imre;Fabian, Agnes;Keri, Szabolcs
精神分裂症的特征是视觉对比敏感度受损和异常的感知体验。本研究的目的是调查这些现象在未经药物治疗的首发精神分裂症患者。视觉对比敏感度的测量与脉冲基座和稳定基座测试，偏向小细胞和大细胞的途径，分别信息处理。异常知觉经验的调查与结构化面试评估知觉异常（SIAPA）。结果显示，精神分裂症患者（n = 20）表现出增加对比敏感度值的大细胞测试相对于对照组（n = 20）。在小细胞条件下，两组之间无显著差异。较高的大细胞对比敏感度值与视觉SIAPA评分增加相关，特别是在两个最低空间频率（0.25和0.5周期/度）。这些结果表明，未经药物治疗的首发精神分裂症，这可能有助于异常的知觉经验和感觉超载的大细胞通路的敏感性提高。
Schizophrenia is characterized by impaired visual contrast sensitivity and anomalous perceptual experiences. The aim of this study was to investigate these phenomena in unmedicated patients with first-episode schizophrenia. Visual contrast sensitivity was measured with pulsed-pedestal and steady-pedestal tests, which bias information processing toward the parvocellular and magnocellular pathways, respectively. Anomalous perceptual experiences were investigated with the Structured Interview for Assessing Perceptual Anomalies (SIAPA). Results revealed that patients with schizophrenia (n = 20) exhibited increased contrast sensitivity values on the magnocellular test relative to the control participants (n = 20). In the parvocellular condition, there was no significant difference between the two groups. The higher magnocellular contrast sensitivity values were associated with increased visual SIAPA scores, especially at the two lowest spatial frequencies (0.25 and 0.5 cycles/degree). These results indicate the heightened sensitivity of magnocellular pathways in unmedicated first-episode schizophrenia, which may contribute to anomalous perceptual experiences and sensory overloading.