Use of alcohol and drugs to self-medicate anxiety disorders in a nationally representative sample
Use of alcohol and drugs to self-medicate anxiety disorders in a nationally representative sample
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DOI：
10.1097/01.nmd.0000244481.63148.98
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发表时间：
2006-11-01
影响因子：
1.9
通讯作者：
Sareen, Jitender
中科院分区：
文献类型：
--
作者：
Bolton, James;Cox, Brian;Sareen, Jitender
本研究在全国代表性样本（N = 5877）中调查了焦虑障碍与酒精和药物的自我药物治疗的患病率及其相关性。采用改良版的综合国际诊断访谈进行DSM-III-R精神障碍诊断。自我药物治疗的频率从7.9%（社交恐惧症，说话亚型）到35.6%（广泛性焦虑障碍）不等。在患有焦虑症的受访者中，自我药物治疗与共病情绪障碍、物质使用障碍、痛苦、自杀意念和自杀企图的可能性增加显著相关。即使在调整了一些社会人口统计学和精神病学变量之后，自我用药行为仍然与自杀意念（调整优势比= 1.66;1.172.36）和自杀企图（调整优势比= 2.23;1.50-3.31）的可能性增加显著相关。这些结果表明，患有焦虑症的人用酒精或药物自我治疗他们的症状，可能会增加情绪和物质使用障碍以及自杀行为的风险。
This study examined the prevalence and correlates of self-medication of anxiety disorders with alcohol and drugs in a nationally representative sample (N = 5877). A modified version of the Composite International Diagnostic Interview was used to make DSM-III-R mental disorder diagnoses. Frequencies of self-medication ranged from 7.9% (social phobia, speaking subtype) to 35.6% (generalized anxiety disorder). Among respondents with an anxiety disorder, self-medication was significantly associated with an increased likelihood of comorbid mood disorders, substance use disorders, distress, suicidal ideation, and suicide attempts. Self-medication behavior remained significantly associated with an increased likelihood of suicidal ideation (adjusted odds ratio = 1.66; 1.172.36) as well as suicide attempts (adjusted odds ratio = 2.23; 1.50-3.31), even after adjusting for a number of sociodemographic and psychiatric variables. These results suggest that individuals with anxiety disorders who self-medicate their symptoms with alcohol or drugs may be at increased risk for mood and substance use disorders and suicidal behavior.