Effects of an osmotically active agent on colonic transit.
Effects of an osmotically active agent on colonic transit.
复制标题
渗透活性剂对结肠运输的影响。
DOI：
10.1111/j.1365-2982.2006.00757.x
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Zinsmeister,AR
中科院分区：
文献类型：
--
作者：
Skoog,SM;Bharucha,AE;Camilleri,M;Burton,DD;Zinsmeister,AR
It is unknown if sorbitol, a widely used laxative agent, accelerates colonic transit, and if these effects are modified by concomitant meal ingestion. Colonic transit was assessed by111In scintigraphy in 40 healthy subjects. After a 24‐h scan, subjects received sorbitol (30 mL of 70% solution) or dextrose (30 mL of 70% solution), administered with or without a meal. Colonic transit, breath hydrogen excretion, and symptom scores were recorded for 4 h thereafter. VAS scores for flatulence, but not other symptoms increased (P= 0.004) by 13.1 ± 6.3 mm (mean ± SEM) on a 100 mm scale after sorbitol alone or sorbitol with a meal (by 18.9 ± 7.2 mm), but not after dextrose. After adjusting for GC24, sorbitol accelerated (P< 0.001) colonic transit (GC28= 3.0 ± 0.3) compared with dextrose (GC28= 2.2 ± 0.2), regardless of meal ingestion. Breath hydrogen excretion was correlated with the change in colonic transit (r = 0.52, P < 0.01) and with flatulence (r = 0.45,P= 0.003) after sugar ingestion. In healthy subjects, sorbitol accelerated colonic transit and increased flatulence but not other symptoms within 4 h, regardless of meal intake.
