The developmental field concept.
The developmental field concept.
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发展领域的概念。
DOI：
10.1002/ajmg.1320210102
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
J. Reynolds
中科院分区：
文献类型：
--
作者：
J. M. Opitz;J. Reynolds
由非整倍体、基因突变、致畸化学物质和某些外科手术等不同原因产生的相同异常表明，胚胎原基作为单位在解剖结构异常的产生中起作用。因此，在正常的个体发育过程中，它们也必须作为单位。在不同的哺乳动物物种中存在相同的畸形，通过共同祖先的后代来识别发育和解剖上的同源性。这些异形和正形反应单位相当于经典实验胚胎学家的表形领域，即胚胎中的那些单位，在这些单位中，适合物种的复杂结构的发育是以空间协调、时间同步和表形分层的方式确定和控制的，既表达了物种非特异性(即系统发育)的信息，也表达了物种特有的遗传编码的发育信息。因此，从长远来看发展是有好处的。
Identical anomalies produced by such different causes as aneuploidy, gene mutation, teratogenic chemicals, and certain surgical procedures show that embryonic primordia respond as units in the production of anomalies of anatomical structure. Hence, they must also act as units during normal ontogeny. The presence of identical malformations in different mammalian species identifies developmental and anatomical homology by virtue of descent from a common ancestor. These dys- and orthomorphogenetically reactive units are the equivalents of the classical experimental embryologist's epimorphic fields, which are those units of the embryo in which the development of complex structures appropriate to the species is determined and controlled in a spatially coordinated, temporally synchronous, and epimorphically hierarchical manner that expresses both species-nonspecific (that is, phylogenetic) and species-specific genetically coded developmental information. Thus, there is some merit in taking a long view of development.