Expression of GABA transporter mRNAs in the developing and adult rat optic nerve
Expression of GABA transporter mRNAs in the developing and adult rat optic nerve
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DOI：
10.1016/s0304-3940(97)00699-x
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发表时间：
1997-10-10
影响因子：
2.5
通讯作者：
Butt, AM
中科院分区：
文献类型：
--
作者：
Howd, AG;Rattray, M;Butt, AM
有电生理学证据表明，γ-氨基丁酸（GABA）和GABA转运蛋白（GATs）在新生大鼠视神经中发挥功能作用，并且在发育过程中下调。本研究的结果直接通过逆转录-聚合酶链反应（RT-PCR）证明了编码GAT-1、-2和-3的mRNA在新生大鼠（5日龄）和成年大鼠的视神经中表达。结果支持GABA在发育中的大鼠视神经中的作用，视神经是一个典型的白色物质束，含有轴突和胶质细胞，但既没有神经元细胞体也没有突触。值得注意的是，GAT mRNA的持续存在表明GABA和胶质细胞摄取机制在成人视神经中具有持久的功能。(C)1997 Elsevier Science爱尔兰有限公司
There is electrophysiological evidence of a functional role for gamma-aminobutyric acid (GABA) and GABA transporters (GATs) in the neonatal rat optic nerve, and that they are down-regulated during development. The results of the present study demonstrate directly by reverse transcription-polymerase chain reaction (RT-PCR) that the mRNAs encoding for GAT-1, -2 and -3 are expressed in the optic nerves of both neonatal (5 day old) and adult rats. The results support a role for GABA in the developing rat optic nerve, a typical white matter tract which contains axons and glia, but neither neuronal cell bodies nor synapses. Significantly, the persistence of GAT mRNAs suggests an enduring function for both GABA and glial uptake mechanisms in the adult optic nerve. (C) 1997 Elsevier Science Ireland Ltd.